| 释义 |
hemoglobinopathyenUK
Thesaurus| Noun | 1. | hemoglobinopathy - a blood disease characterized by the presence of abnormal hemoglobins in the bloodhaemoglobinopathyblood disease, blood disorder - a disease or disorder of the blood |
hemoglobinopathyenUK
hemoglobinopathy[‚hē·mə‚glō·bə′näp·ə·thē] (medicine) Any blood dyscrasia resulting from the genetically determined alteration of the chemical nature of hemoglobin. hemoglobinopathyenUK
hemoglobinopathy [he″mo-glo″bĭ-nop´ah-the] 1. any hematologic disorder due to alteration in the genetically determined molecular structure of hemoglobin, with characteristic clinical and laboratory abnormalities, resulting in conditions such as anemia" >hemolytic anemia, sickle cell anemia, or thalassemia.2. sometimes more specifically, a hemoglobin disorder in which the amino acid sequence is altered, as opposed to thalassemia" >thalassemia, in which there is reduced or absent synthesis of one or more normal polypeptide chain(s).he·mo·glo·bi·nop·a·thy (hē'mō-glō'bi-nop'ă-thē), A disorder or disease caused by or associated with the presence of abnormal hemoglobins in the blood, for example, sickle cell disease, hemoglobin C, D, E, H, or I disorders. Occasionally, combinations of abnormal hemoglobins are seen in hemoglobinopathies. [hemoglobin + G. pathos, disease] hemoglobinopathy Hematology A defect in either α or β hemoglobin, which may be quantitative or qualitative, congenital or–rarely —acquired; while the more common Hb defects–eg, HbS, HbC and thalassemias, cause a characteristic clinical picture, 'rare hemoglobin variants are variously ignored, misunderstood, misdiagnosed, feared, shunned or rejected.' and are not accompanied by clinical disease. See Hemoglobin C disease, Hemoglobin SC disease, Sickle cell anemia, Thalassemia. Hemoglobinopathies–Major Biochemical Forms Sickle Cell Hgb S Sickle/C disease Hgb S, Hgb C Hemoglobin C Disease Hgb C Thalassemia major Hgb F Thalassemia minor Hgb A2 Clinical presentations of hemoglobinopathy Sickling phenotype, eg HbS, HbSC, HbS-Thalassemia Thalassemic phenotype, eg Constant Spring, HbE, Lepore, Kenya, Vicksburg, Indianapolis ↑ oxygen affinity phenotype, eg Bristol, Bucuresti/Louisville, Caribbean, Etobicoke, Hammersmith, Moscva, Okaloosa, Peterborough, Seattle, Torino ↓ oxygen affinity phenotype, eg Altdorf, Istanbul, Baylor, Belfast, Boras, Buenos Aires, Cranston, Duarte, Djelfa, Freiburg, Geneva, Hopkins II, Koln, Lyon, Niteroi, Nottingham, Pasadena, Sabine, Santa Ana, St Louis, Shepherds Bush, Tak, Tours, Toyoake, Tübingen, Zürich
he·mo·glo·bi·nop·a·thy (hē'mō-glō'bi-nop'ă-thē) A disorder or disease caused by or associated with the presence of hemoglobins in the blood.
Synonym(s): haemoglobinopathy. [hemoglobin + G. pathos, disease]he·mo·glo·bi·nop·a·thy (hē'mō-glō'bi-nop'ă-thē) A disorder or disease caused by or associated with the presence of hemoglobins in the blood.
Synonym(s): haemoglobinopathy. [hemoglobin + G. pathos, disease]hemoglobinopathyenUK
Related to hemoglobinopathy: Hemoglobin electrophoresisSynonyms for hemoglobinopathynoun a blood disease characterized by the presence of abnormal hemoglobins in the bloodSynonymsRelated Words- blood disease
- blood disorder
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