hemoglobin C

he·mo·glo·bin C

[MIM*141900.0038] an abnormal Hb with substitution of lysyl residue for glutamyl at the 6th position of the β chain, of formula α₂2^Aβ₂^6Glu→Lys, this type reduces the normal plasticity of erythrocytes. Heterozygotes: Hb C trait, about 28-44% of total Hb is Hb C, no anemia. Homozygotes: nearly all Hb is Hb C, moderate normocytic hemolytic anemia. Patients heterozygous for both Hb C and Hb S (Hb SC disease) and for Hb C and thalassemia are known, and have atypical hemolytic anemias; sickling is enhanced in Hb SC disease.

he·mo·glo·bin C

(Hb C) (hē'mō-glō'bin) An abnormal hemoglobin that affects the physical properties of erythrocytes, causing hemolytic anemia; often found in patients also having sickle cell disease or thalassemia.
Synonym(s): haemoglobin C.

hemoglobin C

A hemoglobin molecule in which lysine is substituted for glutamic acid at the sixth position of the beta chain. This substitution decreases the solubility of the hemoglobin molecule and increases the rigidity of the red blood cell membrane. See also: hemoglobin

单词	hemoglobin c
释义	DictionarySeehemoglobin hemoglobin C hemoglobin C [′hē·mə‚glō·bən ′sē] (pathology) A slow-moving abnormal hemoglobin associated with intraerythrocytic crystal formation, target cells, and chronic hemolytic anemia. hemoglobin C he·mo·glo·bin C [MIM141900.0038] an abnormal Hb with substitution of lysyl residue for glutamyl at the 6th position of the β chain, of formula α₂2^Aβ₂^6Glu→Lys, this type reduces the normal plasticity of erythrocytes. Heterozygotes: Hb C trait, about 28-44% of total Hb is Hb C, no anemia. Homozygotes: nearly all Hb is Hb C, moderate normocytic hemolytic anemia. Patients heterozygous for both Hb C and Hb S (Hb SC disease) and for Hb C and thalassemia are known, and have atypical hemolytic anemias; sickling is enhanced in Hb SC disease. he·mo·glo·bin C (Hb C)* (hē'mō-glō'bin) An abnormal hemoglobin that affects the physical properties of erythrocytes, causing hemolytic anemia; often found in patients also having sickle cell disease or thalassemia. Synonym(s): haemoglobin C. hemoglobin C A hemoglobin molecule in which lysine is substituted for glutamic acid at the sixth position of the beta chain. This substitution decreases the solubility of the hemoglobin molecule and increases the rigidity of the red blood cell membrane. See also: hemoglobin
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