high-grade squamous intraepithelial lesion


high-grade squamous intraepithelial lesion (HSIL, HGSIL),

term used in the Bethesda system for reporting cervical/vaginal cytologic diagnosis to describe a spectrum of noninvasive cervical epithelial abnormalities, including moderate and severe dysplasia, carcinoma in situ, and cervical intraepithelial neoplasia grades 2 and 3.
See also: Bethesda system, ASCUS, atypical glandular cells of undetermined significance, low-grade squamous intraepithelial lesion.

high-grade squamous intraepithelial lesion

Gynecology
A lesion defined by cytologic findings–cells occur singly or in syncytia-like sheets, ↑ nuclear:cytoplasmic ratio, nuclear hyperchromasia that translate into moderate-to-severe dysplasia–CIN 2 to 3/carcinoma in situ of the uterine cervix–a diagnosis made on histology of biopsied tissue, a precancerous lesion. Cf Low-grade squamous intraepithelial lesion.

high-grade squa·mous in·tra·ep·i·the·li·al le·sion

(HSIL, HGSIL) (hī-grād skwā'mŭs in'tră-ep-i-thē'lē-ăl lē'zhŭn) Term used in the Bethesda system for reporting cervical-vaginal cytologic diagnosis to describe a spectrum of noninvasive cervical epithelial abnormalities, including moderate and severe dysplasia, carcinoma in situ, and cervical intraepithelial neoplasia grades 2 and 3.
See also: Bethesda system, ASCUS, atypical glandular cells of undetermined significance, low-grade squamous intraepithelial lesion

high-grade squamous intraepithelial lesion

Abbreviation: HGSIL
A premalignant squamous lesion, found on the Papanicolaou test, which may be moderate dysplasia, severe dysplasia, or carcinoma in situ.

Patient care

Treatment requires removal or destruction of the affected cells, usually with loop electrosurgical excision procedure (LEEP) or ablation. Left untreated, HGSIL may progress to invasive cervical cancer.

See also: lesion