fusin

enUK

fu·sin

(fyū'zin), A G protein-linked receptor present on certain human cells that is thought to be required for HIV fusion with a target cell. [fuse, fr. L. fundo, pp. fusum, to melt, + -in]

CXCR4

A gene on chromosome 2q21 that encodes a seven-transmembrane G protein-coupled receptor belonging to the CXC chemokine receptor family, which binds specifically to stromal cell-derived factor-1, transducing a signal by increasing intracellular calcium ions and enhancing MAPK1/MAPK3 activation. It acts as a receptor for extracellular ubiquitin, is involved in haematopoiesis and in cardiac ventricular septum formation, plays a role in gastrointestinal tract vascularisation by regulating vascular branching and/or remodelling in endothelial cells, may be involved in cerebellar development and, in the CNS, may mediate hippocampal-neuron survival.
Molecular pathology
CXCR4 acts with the CD4 to support HIV entry into cells; it is highly expressed in breast cancer cells. CXCR4 mutations cause WHIM (warts, hypogammaglobulinaemia, infections, and myelokathexis) syndrome.

fu·sin

(fyū'zin) A G protein-linked receptor present on certain human cells that is thought to be required for HIV fusion with a target cell. [fuse, fr. L. fundo, pp. fusum, to melt, + -in]

单词	fusin
释义	DictionarySeeFuxin fusin enUK fu·sin (fyū'zin), A G protein-linked receptor present on certain human cells that is thought to be required for HIV fusion with a target cell. [fuse, fr. L. fundo, pp. fusum, to melt, + -in] CXCR4 A gene on chromosome 2q21 that encodes a seven-transmembrane G protein-coupled receptor belonging to the CXC chemokine receptor family, which binds specifically to stromal cell-derived factor-1, transducing a signal by increasing intracellular calcium ions and enhancing MAPK1/MAPK3 activation. It acts as a receptor for extracellular ubiquitin, is involved in haematopoiesis and in cardiac ventricular septum formation, plays a role in gastrointestinal tract vascularisation by regulating vascular branching and/or remodelling in endothelial cells, may be involved in cerebellar development and, in the CNS, may mediate hippocampal-neuron survival. Molecular pathology CXCR4 acts with the CD4 to support HIV entry into cells; it is highly expressed in breast cancer cells. CXCR4 mutations cause WHIM (warts, hypogammaglobulinaemia, infections, and myelokathexis) syndrome. fu·sin (fyū'zin) A G protein-linked receptor present on certain human cells that is thought to be required for HIV fusion with a target cell. [fuse, fr. L. fundo, pp. fusum, to melt, + -in]
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