| 单词 | g-csf | |||
| 释义 | G-CSFG-CSFG-CSFG-CSFG-CSFA biological response modifier encoded by CSF3 on chromosome 17q11.2-q12, which is produced by endothelial cells, fibroblasts, and macrophages. It stimulates granulocyte production in bone marrow (BM), acting synergistically with IL-3 to stimulate proliferation of other marrow cells. The recombinant DNA form is filgrastim (Neupogen).Activity G-CSF stimulates granulocyte production in BM suppressed by chemotherapy and radiotherapy, and reduces infections in cancer patients. It can induce terminal maturation of myeloid leukaemia cells, resulting in complete haematologic and cytologic remission, and can suppress self-renewal. It is useful in patients with AIDS or leukaemic relapse after allogeneic BM transplantation. Adverse effects Nausea, bone pain, rash. G-CSFGranulocyte colony-stimulating factor Molecular therapeutics A biological response modifier, the recombinant DNA form of which is filgrastim–Neupogen® Activity G-CSF stimulates granulocyte production in BM suppressed by chemotherapy, RT, serving to ↓ infections in Pts with malignancy; G-CSF can induce terminal maturation of myeloid leukemia cell lines and suppress self-renewal, and is thus useful in Pts with AIDS or leukemic relapse after allogeneic BMT Adverse effects Nausea, bone pain, rash. See Biological response modifiers, Colony-stimulating factors. Cf GM-CSF.G-CSFG-CSF
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