gold compound


Any second-line gold-based anti-rheumatic—e.g., aurothioglucose, gold sodium thiomalate, auranofin—used to treat rheumatoid arthritis and other arthropathies, which protects membrane proteins and lipids from oxidative degradation and quench singlet O2 generated as free radicals
Adverse effects GI tract (e.g., diarrhoea, abdominal pain, nausea, vomiting—partially relieved by cromolyn sodium), renal (e.g., nephrotic syndrome, proteinuria, rash, blood dyscrasias, hepatitis)

gold compound

Rheumatology Any 2nd-line gold-based anti-rheumatic–eg, aurothioglucose, gold sodium thiomalate, auranofin to treat rheumatoid arthritis and other arthropathies Side effects GI tract–eg diarrhea, abdominal pain, N&V, partially relieved by cromolyn sodium, renal–eg, nephrotic syndrome, proteinuria, rash, blood dyscrasias, hepatitis. See Gold lung.