释义 |
DictionarySeeproteinglial fibrillary acidic protein
glial fibrillary acidic protein [MIM*137780] a cytoskeletal protein of 51 kD found in fibrillary astrocytes; stains for this protein are frequently used to assist in the differential diagnosis of neurologic lesions.GFAP A gene on chromosome 17q21 that encodes a major class-III intermediate filament protein of mature astrocytes, which serves as a marker (in histopathology) to distinguish astrocytes from other glial cells, both during development and in tumour diagnostics. Molecular pathology Defects in GFAP are linked to Alexander disease.gli·al fib·ril·la·ry a·cid·ic pro·tein (glī'ăl fib'ri-lar-ē ă-sid'ik prō'tēn) A cytoskeletal protein of 51 kD found in fibrous astrocytes; stains for this protein are frequently used to assist in the differential diagnosis of neurologic lesions. glial fibrillary acidic protein Abbreviation: GFAP An intermediate filament found only in astrocytes and astroglial cells. It forms part of the skeletal structure of neurons. Abnormalities in GFAP are found in a variety of neurological diseases, including Alzheimer's disease, Creutzfeldt-Jakob disease, and some brain tumors. See also: proteinSee GFAB See GFAB |