acute myeloid leukaemia

A rapidly progressing form of leukaemia characterised by the proliferation of immature WBCs (blasts in peripheral circulation).

Epidemiology
Primarily in adults or infants under age 1; 2,000 new cases are diagnosed/year, UK.

Clinical findings
Fatigue, weight-loss, fever, weakness, pallor, bone and joint pain, bleeding gums, nosebleeds, bruising, lymphadenopathy.

Complications
Bleeding, increased infections.

Management
Chemotherapy, bone marrow transplantation.
FAB classification, acute leukaemias
Acute myeloid leukaemia (AML)
M0—Myeloblasts with minimal differentiation.
M1—Myeloblasts without maturation.
M2—Myeloblasts with maturation (best AML prognosis).
M3—Hypergranular promyelocytic leukaemia (faggot cells).
M3V—Variant, microgranular promyelocytic leukaemia.
M4—Myelomonocytic leukocytes.
M5—Monocytic, subtype:
a. Poorly differentiated monocytic leukaemia.
b. Well-differentiated monocytic leukaemia.
M6—Erythroleukaemia/DiGuglielmo syndrome.
M7—Megakaryocytic leukaemia—pleomorphic undifferentiated cells with cytoplasmic blebs; myelofibrosis or increased marrow reticulin; positive for platelet peroxidase antifactor VIII.
WHO classification
AML with recurrent cytogenetic abnormalities.
AML with multi-lineage dysplasia (as a precursor to myelodysplastic syndrome).
AML related to therapy.
AML NOS.
AML variants
AML with recurrent cytogenetic abnormalities.
AML with t(8;21)(q22;q22).
AML with inv(16)(p13q22).
AML with t(15;17)(q22;q12).
AML with 11q23 (MLL) abnormalities.
AML with multilineage dysplasia.
AML (and MDS), therapy-related:
• Alkylating agent related;
• Topoisomerase-II inhibitor related.
AML, not otherwise categorised.

acute myeloid leukaemia

A form of LEUKAEMIA in which the cells present in abnormal numbers are derived from primitive precursors, in the bone marrow, of the white blood cells. The median age of presentation is 70. Genetic defects and age-related factors are thought to be the principal determinants of lack of success of chemotherapy in elderly patients.

单词	acute myeloid leukaemia
释义	DictionarySeeacute myeloid leukemiaEncyclopediaSeeAML acute myeloid leukaemia acute myeloid leukaemia A rapidly progressing form of leukaemia characterised by the proliferation of immature WBCs (blasts in peripheral circulation). Epidemiology Primarily in adults or infants under age 1; 2,000 new cases are diagnosed/year, UK. Clinical findings Fatigue, weight-loss, fever, weakness, pallor, bone and joint pain, bleeding gums, nosebleeds, bruising, lymphadenopathy. Complications Bleeding, increased infections. Management Chemotherapy, bone marrow transplantation. FAB classification, acute leukaemias Acute myeloid leukaemia (AML) M0—Myeloblasts with minimal differentiation. M1—Myeloblasts without maturation. M2—Myeloblasts with maturation (best AML prognosis). M3—Hypergranular promyelocytic leukaemia (faggot cells). M3V—Variant, microgranular promyelocytic leukaemia. M4—Myelomonocytic leukocytes. M5—Monocytic, subtype: a. Poorly differentiated monocytic leukaemia. b. Well-differentiated monocytic leukaemia. M6—Erythroleukaemia/DiGuglielmo syndrome. M7—Megakaryocytic leukaemia—pleomorphic undifferentiated cells with cytoplasmic blebs; myelofibrosis or increased marrow reticulin; positive for platelet peroxidase antifactor VIII. WHO classification AML with recurrent cytogenetic abnormalities. AML with multi-lineage dysplasia (as a precursor to myelodysplastic syndrome). AML related to therapy. AML NOS. AML variants AML with recurrent cytogenetic abnormalities. AML with t(8;21)(q22;q22). AML with inv(16)(p13q22). AML with t(15;17)(q22;q12). AML with 11q23 (MLL) abnormalities. AML with multilineage dysplasia. AML (and MDS), therapy-related: • Alkylating agent related; • Topoisomerase-II inhibitor related. AML, not otherwise categorised. acute myeloid leukaemia A form of LEUKAEMIA in which the cells present in abnormal numbers are derived from primitive precursors, in the bone marrow, of the white blood cells. The median age of presentation is 70. Genetic defects and age-related factors are thought to be the principal determinants of lack of success of chemotherapy in elderly patients.
随便看	siricidae siricoidea sir, i do not know siri eyes free sirif siri guru granth sahib sirih sirij sirim sirimavo bandaranaike sirimavo ratwatte dias bandaranaike sirin siring sirio siriometer siriono siriono language sirionó sirionó language siris sir isaac newton sir isaac pitman sir isaak newton sir isaiah berlin siris (disambiguation)