| Acronym | Definition |
|---|
| GISS➣Goddard Institute for Space Studies |
| GISS➣Geographic Information System Specialist |
| GISS➣Gone in Sixty Seconds (movie) |
| GISS➣Gerencia de Informática de la Seguridad Social (Social Security Department for Information Technology Management; Spain) |
| GISS➣Global Interconnect Sizing and Spacing |
| GISS➣General Impression Shape and Size |
| GISS➣Gordonstoun International Summer School (Scotland) |
| GISS➣Guidance Interface Subsystem |
| GISS➣Gosh, I’m So Surprised! (Sci-Fi fandom) |