cold agglutinin disease

Cold agglutinin syndrome Clinical immunology An immune disorder characterized by IgM autoantibodies that optimally agglutinate RBCs at very low temperatures–eg, 4ºC; low titers–< 1:32 of cold agglutinins–CAs are detectable in many normal subjects; polyclonal CAs ↑ after certain infections–eg, mycoplasma, CMV, EBV, trypanosomiasis, and malaria, peak in 2-3 wks and are insignificant if non-hemolytic; CAs may occur in any Pt with acquired hemolytic anemia and a positive direct Coomb's test; certain antibodies have been implicated–eg, anti-I, -i, -Pr, -Gd, Sd^a. See Autoantibody. Cf 'Room temps. '.

cold agglutinin disease

Any of a group of disorders marked by hemolytic anemia, obstruction of the microcirculation, or both. It is caused by agglutination of red blood cells by immunoglobulins that precipitate at cool or cold temperatures. The most common symptom is Raynaud's phenomenon. Cold agglutinin disease often occurs transiently after infection with Mycoplasma pneumoniae or Epstein-Barr virus. Often the cause is idiopathic.

单词	cold agglutinin disease
释义	DictionarySeeagglutininEncyclopediaSeecold agglutinin cold agglutinin disease cold agglutinin disease Cold agglutinin syndrome Clinical immunology An immune disorder characterized by IgM autoantibodies that optimally agglutinate RBCs at very low temperatures–eg, 4ºC; low titers–< 1:32 of cold agglutinins–CAs are detectable in many normal subjects; polyclonal CAs ↑ after certain infections–eg, mycoplasma, CMV, EBV, trypanosomiasis, and malaria, peak in 2-3 wks and are insignificant if non-hemolytic; CAs may occur in any Pt with acquired hemolytic anemia and a positive direct Coomb's test; certain antibodies have been implicated–eg, anti-I, -i, -Pr, -Gd, Sd^a. See Autoantibody. Cf 'Room temps. '. cold agglutinin disease Any of a group of disorders marked by hemolytic anemia, obstruction of the microcirculation, or both. It is caused by agglutination of red blood cells by immunoglobulins that precipitate at cool or cold temperatures. The most common symptom is Raynaud's phenomenon. Cold agglutinin disease often occurs transiently after infection with Mycoplasma pneumoniae or Epstein-Barr virus. Often the cause is idiopathic.
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