单词 | diphosphonate |
释义 | diphosphonatedi·phos·pho·nateD5242750 (dī′fŏs′fə-nāt′)diphosphonatediphosphonate[di-fos´fo-nāt]diphosphonate(dī′fŏs′fə-nāt′)bisphosphonateAny of a family of drugs with two phosphonate (PO3) groups, which inhibit enzymes that break down pyrophosphate. Bisphosphonates include etidronate and clodronate (first-generation agents), and pamidronate disodium (a second-generation bisphosphonate), which inhibits bone resorption at doses that do not affect bone mineralisation. Bisphosphonates are potent inhibitors of bone resorption that bind tightly to the hydroxyapatite crystals, and have therapeutic potential in osteoporosis and in advanced (stage-III) multiple myeloma and Paget’s disease of bone.Indications Treat and prevent osteoporosis, osteolysis due to metastatic breast and prostate cancer, multiple myeloma, Paget's disease of bone, fibrous dysplasia, Gaucher's disease, etc. Adverse effect Upset stomach, gastritis, oesophageal erosions; long-term effects include femoral fractures and an increased risk of oesophageal cancer. Agents Etidronate, clodronate, tiludronate. |
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