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estrone
es·trone E0223300 (ĕs′trōn′)n. An estrogenic hormone, C18H22O2, that is secreted by the ovaries and by fatty tissue. It is the main form of estrogen in postmenopausal women.
[estr(us) + -one.]estrone (ˈɛstrəʊn; ˈiːstrəʊn) n (Biochemistry) the usual US spelling of oestronees•trone (ˈɛs troʊn)
n. an estrogenic hormone, C18H22O2, produced by the ovarian follicles and found during pregnancy in urine and placental tissue. [1930–35; estr(in) an earlier name (estr(us) + -in1) + -one] Thesaurus| Noun | 1. | estrone - a naturally occurring weak estrogenic hormone secreted by the mammalian ovary; synthesized (trade name Estronol) and used to treat estrogen deficiencyEstronol, oestrone, theelinestrogen, oestrogen - a general term for female steroid sex hormones that are secreted by the ovary and responsible for typical female sexual characteristicsketosteroid - a steroid containing a ketone group |
TranslationsEstrone
estrone[′e‚strōn] (biochemistry) C18H22O2 An estrogenic hormone produced by follicle cells of the vertebrate ovary; functions the same as estradiol. Estrone C18H22O2, a female sex hormone of the estrogen group. Estrone occurs as colorless crystals with a melting point of 259°C. Poorly soluble in water, it dissolves better in organic solvents. It is optically active, with a specific rotation of [α]D= +170°. Estrone was first isolated in 1929 from the urine of pregnant women by A. Butenandt and the American biochemist E. Doisy. Specific sources rich in the hormone are the urine and testes of stallions. The hormone is readily converted both metabolically and chemically into estradiol, a hormone that has higher estrogenic activity. Estrone is found not only in animals and humans, but also in certain fruits, such as the coconut, apple, and pomegranate. Because its structure is so simple, many methods for the complete chemical synthesis of estrone have been developed. The most economical of these was suggested by the Soviet scientist I. V. Torgov in 1962. Estrone has important physiological functions (see). estrone
estrone [es´trōn] an estrogen isolated from pregnancy urine, the human placenta, and palm kernel oil, and also prepared synthetically; used in therapy" >estrogen replacement therapy for hypogonadism, ovariectomy, primary ovarian failure, atrophic vaginitis, vasomotor menopausal symptoms such as hot flashes, and vulvar atrophy, and in the treatment of dysfunctional uterine bleeding and advanced prostate cancer. Administered intramuscularly or intravaginally. See also estrogens" >conjugated estrogens and estrogens" >esterified estrogens.es·trone (E1), (es'trōn), A metabolite of 17β-estradiol, commonly found in urine, ovaries, and placenta; has considerably less biologic activity than the parent hormone. Synonym(s): follicular hormone, folliculin, ketohydroxyestrin, oestroneestrone (ĕs′trōn′)n. An estrogenic hormone, C18H22O2, that is secreted by the ovaries and by fatty tissue. It is the main form of estrogen in postmenopausal women.estrone E1 An estrogen with very low biologic activity that is the major source of estrogen in children and postmenopausal ♀ ↑ in pregnancy, postmenopausal, ↑ age, obesity, luteal phase of menstrual cycle ↓ in hypogonadism. See Androstendione. es·trone (es'trōn) A metabolite of 17β-estradiol, commonly found in urine, ovaries, and placenta, with considerably less biologic activity than the parent hormone.
Synonym(s): oestrone. estrone
Related to estrone: estriolSynonyms for estronenoun a naturally occurring weak estrogenic hormone secreted by the mammalian ovarySynonymsRelated Words- estrogen
- oestrogen
- ketosteroid
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