| 释义 |
anchorage dependence an·chor·age de·pen·dencethe need of normal cells for an appropriate surface to be attached to for them to grow in culture.The requirement by normal cells to attach to a surface to grow and divide in vitro; when cells lose anchorage dependence they no longer respond to external growth controls, which often correlates with tumourigenicity in vivo. It is a hallmark of malignant transformation and can be induced by oncogenic virusesanchorage dependence A property of cells that can grow and proliferate only if fixed to a substrate. Many cancer cells do not show anchorage dependence and can be grown in a liquid culture. |