单词 | activin |
释义 | activinenUKac·ti·vinA0071150 (ăk′tə-vĭn, ăk-tĭv′ĭn)activinenUKac·tiv·in(ak'ti-vin),activin(ăk′tə-vĭn, ăk-tĭv′ĭn)ActivinEither of two dimeric proteins belonging to the TGF-beta superfamily (as do inhibin and bone morphogenic protein) which act primarily through SMADs, a class of signal transducers, which are involved in DNA-binding and signal transduction. Activins are involved in all stages of the cell cycle: proliferation, differentiation, metabolism, homeostasis, and death (apoptosis), as well as immune response and tissue repair—activins A and B are highly expressed during wound repair and healing, and have yin-yang relationship with inhibin. Activins are involved in differentiation of erythroid precursors and erythroleukemia cell lines, neuronal survival, stimulation of insulin and anterior pituitary hormone secretion, regulation of the menstrual cycle, increasing FSH production and granulosa cell differentiation by binding to follistatin, an FSH release inhibitor.ac·tiv·in(ak'ti-vin) |
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