bumetanide

[bu-met´ah-nīd] a loop diuretic used in treatment of edema, such as that associated with heart failure" >congestive heart failure or hepatic or renal disease, treatment of hypertension, usually in association with other drugs, and as an adjunct in treatment of acute pulmonary edema; administered orally, intramuscularly, or intravenously.

bumetanide

Bumetanide Injection

Pharmacologic class: Loop diuretic

Therapeutic class: Antihypertensive

Pregnancy risk category C

FDA Box Warning

• Drug is a potent diuretic; excessive amounts may cause profound diuresis with fluid and electrolyte depletion. Give only under careful medical supervision; adjust dosage and dosing schedule to patient's needs.

Action

Inhibits reabsorption of sodium and chloride in distal renal tubules and ascending limb of loop of Henle; increases renal excretion of water, sodium, chloride, magnesium, hydrogen, and calcium. Also reduces increased fluid volume caused by renal vasodilation.

Availability

Injection: 0.25 mg/ml

Tablets: 0.5 mg, 1 mg, 2 mg

Indications and dosages

➣ Edema caused by heart failure or hepatic or renal disease; adult nocturia

Adults: 0.5 to 2 mg/day P.O. as a single dose; up to two additional doses may be given q 4 to 5 hours (up to 10 mg/day). Or 0.5 to 1 mg I.V. or I.M., repeated q 2 to 3 hours as needed, up to 10 mg/day.

➣ Hypertension

Adults: 0.5 mg/day P.O. Maximum dosage is 5 mg/day.

Dosage adjustment

• Renal impairment

• Elderly patients

Off-label uses

• Drug-related edema

• Hypercalcemia

Contraindications

• Hypersensitivity to drug or sulfonamides

• Uncorrected electrolyte imbalances

• Hepatic coma

• Anuria and oliguria

Precautions

Use cautiously in:

• severe hepatic disease, electrolyte depletion, diabetes mellitus, worsening azotemia

• elderly patients

• pregnant or breastfeeding patients

• children younger than age 18.

Administration

• Know that oral or I.V. route is preferred, because I.M. administration may cause pain at injection site.

• Be aware that drug may be given alone or with other antihypertensives.

• Dilute with dextrose 5% in water, normal saline solution, or lactated Ringer's injection.

• Give I.V. dose slowly over 2 minutes.

• Give P.O. form with food or milk.

Adverse reactions

CNS: dizziness, headache, insomnia, nervousness, vertigo, weakness, paresthesia, confusion, fatigue, hand-flapping tremor, encephalopathy

CV: hypotension, ECG changes, chest pain, thrombophlebitis, arrhythmias

EENT: blurred vision, nystagmus, hearing loss, tinnitus

GI: nausea, vomiting, diarrhea, constipation, dyspepsia, gastric irritation, dry mouth, anorexia, acute pancreatitis

GU: polyuria, nocturia, glycosuria, premature ejaculation, difficulty maintaining erection, oliguria, renal failure

Hepatic: jaundice

Metabolic: dehydration, hyperglycemia, hyperuricemia, hypokalemia, hypomagnesemia, hypochloremic alkalosis

Musculoskeletal: arthralgia; muscle cramps, aching, or tenderness

Skin: photosensitivity, hives, rash, pruritus, urticaria, diaphoresis

Other: pain, nipple tenderness

Interactions

Drug-drug. Aminoglycosides, cisplatin: increased risk of ototoxicity

Amphotericin B, corticosteroids, mezlocillin, other diuretics, piperacillin, stimulant laxatives: additive hypokalemia

Anticoagulants, thrombolytics: increased bumetanide effects

Antihypertensives, nitrates: additive hypotension

Cardiac glycosides: increased risk of digoxin toxicity

Lithium: decreased lithium excretion, possible lithium toxicity

Neuromuscular blockers: prolonged neuromuscular blockade

Nonsteroidal anti-inflammatory drugs, probenecid: inhibition of diuretic response

Drug-diagnostic tests. Blood urea nitrogen (BUN), cholesterol, creatinine, glucose, nitrogenous compounds: increased levels

Calcium, magnesium, platelets, potassium, sodium: decreased levels

Drug-herbs. Dandelion: interference with diuretic activity

Ginseng: resistance to diuresis

Licorice: rapid potassium loss

Drug-behaviors. Acute alcohol ingestion: additive hypotension

Patient monitoring

• Weigh patient at start of therapy, and monitor weight throughout therapy.

• Monitor blood pressure regularly.

• Monitor serum electrolyte, uric acid, glucose, and BUN levels.

• Monitor elderly patients for extreme blood pressure changes, orthostatic hypotension, and dehydration.

Patient teaching

• Advise patient to take drug in morning to prevent nocturia, and to take second dose (if required) in late afternoon.

• Instruct patient to move slowly when sitting up or standing, to avoid dizziness or light-headedness from sudden blood pressure drop.

• Caution patient to avoid alcohol because of increased risk of hypotension.

• Advise patient to eat foods high in potassium. Provide other dietary counseling as appropriate to help prevent or minimize electrolyte imbalances.

• Instruct patient to weigh himself often to help detect fluid retention.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.

bumetanide

(byo͞o-mĕt′ə-nīd′)n. A diuretic, C₁₇H₂₀N₂O₅S₂, used in the treatment of edema associated with congestive heart failure, hepatic cirrhosis, and renal disease.

bumetanide

A potent loop diuretic with a rapid onset but short duration of action, which is used for patients with congestive heart failure who respond poorly to furosemide.

Adverse effects
Hypotension (especially orthostatic), drowsiness, headache.

bumetanide

Bumex^® Cardiology A loop diuretic with a rapid onset but short duration of action indicated for Pts with HTN and CHF Contraindications Not indicated due to hypovolemia and fetal hypoxia. See Diuretic, Loop diuretic.

bumetanide

A quick-acting DIURETIC drug used to relieve the fluid retention (OEDEMA) occurring in HEART FAILURE, kidney disease such as the NEPHROTIC SYNDROME and liver CIRRHOSIS. A brand name is Burinex.

单词	bumetanide
释义	bumetanide bu·met·a·nide B5560950 (byo͞o-mĕt′ə-nīd′)n. A diuretic, C₁₇H₂₀N₂O₅S₂, used in the treatment of edema associated with congestive heart failure, hepatic cirrhosis, and renal disease. [Probably bu(tyl) + meta- + (sulfo)n(yl) + (am)ide.] Translations bumetanide bumetanide [bu-met´ah-nīd] a loop diuretic used in treatment of edema, such as that associated with heart failure" >congestive heart failure or hepatic or renal disease, treatment of hypertension, usually in association with other drugs, and as an adjunct in treatment of acute pulmonary edema; administered orally, intramuscularly, or intravenously. bumetanide Bumetanide Injection *Pharmacologic class:* Loop diuretic *Therapeutic class:* Antihypertensive *Pregnancy risk category C* FDA Box Warning • Drug is a potent diuretic; excessive amounts may cause profound diuresis with fluid and electrolyte depletion. Give only under careful medical supervision; adjust dosage and dosing schedule to patient's needs. Action Inhibits reabsorption of sodium and chloride in distal renal tubules and ascending limb of loop of Henle; increases renal excretion of water, sodium, chloride, magnesium, hydrogen, and calcium. Also reduces increased fluid volume caused by renal vasodilation. Availability Injection: 0.25 mg/ml Tablets: 0.5 mg, 1 mg, 2 mg Indications and dosages ➣ Edema caused by heart failure or hepatic or renal disease; adult nocturia Adults: 0.5 to 2 mg/day P.O. as a single dose; up to two additional doses may be given q 4 to 5 hours (up to 10 mg/day). Or 0.5 to 1 mg I.V. or I.M., repeated q 2 to 3 hours as needed, up to 10 mg/day. ➣ Hypertension Adults: 0.5 mg/day P.O. Maximum dosage is 5 mg/day. Dosage adjustment • Renal impairment • Elderly patients Off-label uses • Drug-related edema • Hypercalcemia Contraindications • Hypersensitivity to drug or sulfonamides • Uncorrected electrolyte imbalances • Hepatic coma • Anuria and oliguria Precautions Use cautiously in: • severe hepatic disease, electrolyte depletion, diabetes mellitus, worsening azotemia • elderly patients • pregnant or breastfeeding patients • children younger than age 18. Administration • Know that oral or I.V. route is preferred, because I.M. administration may cause pain at injection site. • Be aware that drug may be given alone or with other antihypertensives. • Dilute with dextrose 5% in water, normal saline solution, or lactated Ringer's injection. • Give I.V. dose slowly over 2 minutes. • Give P.O. form with food or milk. Adverse reactions CNS: dizziness, headache, insomnia, nervousness, vertigo, weakness, paresthesia, confusion, fatigue, hand-flapping tremor, encephalopathy CV: hypotension, ECG changes, chest pain, thrombophlebitis, arrhythmias EENT: blurred vision, nystagmus, hearing loss, tinnitus GI: nausea, vomiting, diarrhea, constipation, dyspepsia, gastric irritation, dry mouth, anorexia, acute pancreatitis GU: polyuria, nocturia, glycosuria, premature ejaculation, difficulty maintaining erection, oliguria, renal failure Hepatic: jaundice Metabolic: dehydration, hyperglycemia, hyperuricemia, hypokalemia, hypomagnesemia, hypochloremic alkalosis Musculoskeletal: arthralgia; muscle cramps, aching, or tenderness Skin: photosensitivity, hives, rash, pruritus, urticaria, diaphoresis Other: pain, nipple tenderness Interactions Drug-drug. Aminoglycosides, cisplatin: increased risk of ototoxicity Amphotericin B, corticosteroids, mezlocillin, other diuretics, piperacillin, stimulant laxatives: additive hypokalemia Anticoagulants, thrombolytics: increased bumetanide effects Antihypertensives, nitrates: additive hypotension Cardiac glycosides: increased risk of digoxin toxicity Lithium: decreased lithium excretion, possible lithium toxicity Neuromuscular blockers: prolonged neuromuscular blockade Nonsteroidal anti-inflammatory drugs, probenecid: inhibition of diuretic response Drug-diagnostic tests. Blood urea nitrogen (BUN), cholesterol, creatinine, glucose, nitrogenous compounds: increased levels Calcium, magnesium, platelets, potassium, sodium: decreased levels Drug-herbs. Dandelion: interference with diuretic activity Ginseng: resistance to diuresis Licorice: rapid potassium loss Drug-behaviors. Acute alcohol ingestion: additive hypotension Patient monitoring • Weigh patient at start of therapy, and monitor weight throughout therapy. • Monitor blood pressure regularly. • Monitor serum electrolyte, uric acid, glucose, and BUN levels. • Monitor elderly patients for extreme blood pressure changes, orthostatic hypotension, and dehydration. Patient teaching • Advise patient to take drug in morning to prevent nocturia, and to take second dose (if required) in late afternoon. • Instruct patient to move slowly when sitting up or standing, to avoid dizziness or light-headedness from sudden blood pressure drop. • Caution patient to avoid alcohol because of increased risk of hypotension. • Advise patient to eat foods high in potassium. Provide other dietary counseling as appropriate to help prevent or minimize electrolyte imbalances. • Instruct patient to weigh himself often to help detect fluid retention. • As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above. bumetanide (byo͞o-mĕt′ə-nīd′)n. A diuretic, C₁₇H₂₀N₂O₅S₂, used in the treatment of edema associated with congestive heart failure, hepatic cirrhosis, and renal disease. bumetanide A potent loop diuretic with a rapid onset but short duration of action, which is used for patients with congestive heart failure who respond poorly to furosemide. Adverse effects Hypotension (especially orthostatic), drowsiness, headache. bumetanide Bumex^® Cardiology A loop diuretic with a rapid onset but short duration of action indicated for Pts with HTN and CHF Contraindications Not indicated due to hypovolemia and fetal hypoxia. See Diuretic, Loop diuretic. bumetanide A quick-acting DIURETIC drug used to relieve the fluid retention (OEDEMA) occurring in HEART FAILURE, kidney disease such as the NEPHROTIC SYNDROME and liver CIRRHOSIS. A brand name is Burinex.
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bumetanide

bu·met·a·nide

bumetanide

bumetanide

bumetanide

FDA Box Warning

Action

Availability

Indications and dosages

Dosage adjustment

Off-label uses

Contraindications

Precautions

Administration

Adverse reactions

Interactions

Patient monitoring

Patient teaching

bumetanide

bumetanide

bumetanide

bumetanide