clusterin


clusterin

 [klus´ter-in] a multifunctional glycoprotein with roles in the metabolism and transport of lipids and membrane fragments, secretion of hormones, reproductive biology, inhibition of assembly of the complex" >membrane attack complex of complement activation, programmed cell death, and modulation of intercell interactions; its expression is enhanced in tissue injury and remodeling as well as in degenerative diseases such as alzheimer's disease.

clusterin

(klŭs'tĕr-in), Heterodimeric highly conserved secreted glycoprotein, which is expressed in a wide variety of tissues and found in all human fluids; implicated in physiologic processes such as sperm maturation, lipid transportation, complement inhibition, tissue remodeling, membrane recycling, cell-cell and cell-substratum interactions, stabilization of stressed proteins in a folding-competent state and promotion or inhibition of apoptosis. Synonym(s): apolipoprotein J

clusterin

(klus'te-rin) [ cluster + -in],

CLU.

A multifunctional cell-protective glycoprotein (molecular weight 75-80 kDa) found in many tissues. High levels of CLU are found in cells undergoing apoptosis. Synonym: apolipoprotein J