| Acronym | Definition |
|---|
| ESPN➣Entertainment and Sports Programming Network |
| ESPN➣East Penn Railroad (Kennett Square, PA) |
| ESPN➣Economic, Social, Political, Environmental |
| ESPN➣European Society for Paediatric Nephrology (est. 1967) |
| ESPN➣Enological Society of the Pacific Northwest (wine enthusiasts' organization) |
| ESPN➣European Society for Pediatric Neurosurgery (est. 1967) |
| ESPN➣Équipements sous Pression Nucléaires (French: Equipment Under Nuclear Pressure) |
| ESPN➣Extended Stochastic Petri Net (mathematical engineering) |
| ESPN➣Eastside Suburban Peace Network (Seattle, WA) |