FBXW4

A gene on chromosome 10q24 that encodes a member of the F-box/WD-40 gene family, which recruit specific target proteins by WD-40 protein-protein-binding domains for phosphorylation-dependent ubiquitination and ubiquitin-mediated degradation of targeted proteins. A knockout mouse model of FBXW4 results in absent central digits, underdeveloped/absent metacarpal/metatarsal bones and syndactyly, which is similar to a human counterpart; split hand/foot malformation with an autosomal recessive form characterised by complex rearrangements and duplications map to 10q24.

单词	fbxw4
释义	DictionarySeeDAC FBXW4 FBXW4 A gene on chromosome 10q24 that encodes a member of the F-box/WD-40 gene family, which recruit specific target proteins by WD-40 protein-protein-binding domains for phosphorylation-dependent ubiquitination and ubiquitin-mediated degradation of targeted proteins. A knockout mouse model of FBXW4 results in absent central digits, underdeveloped/absent metacarpal/metatarsal bones and syndactyly, which is similar to a human counterpart; split hand/foot malformation with an autosomal recessive form characterised by complex rearrangements and duplications map to 10q24.
随便看	acholuric jaundice achomawi achomawis achondrite achondrites achondritic achondriticly achondrodysplasia achondrodysplasia, type 1b achondrogenesis achondrogenesis, fraccaro type achondrogenesis, houston-harris type achondrogenesis syndrome achondrogenesis type 1a achondrogenesis, type 1a achondrogenesis type 1b achondrogenesis type 2 achondrogenesis, type 2 achondrogenesis type ia achondrogenesis, type ia achondrogenesis type ib achondrogenesis type ii achondrogenesis, type ii achondroplasia achondroplasia tarda