besifloxacin

besifloxacin

(be-si-flox-a-sin) besifloxacin,

Besivance

(trade name)

Classification

Therapeutic: anti infectives
Pharmacologic: fluoroquinolones
Pregnancy Category: C

Indications

Treatment of bacterial conjunctivitis.

Action

Inhibits bacterial DNA synthesis by inhibiting DNA gyrase.

Therapeutic effects

Death of susceptible bacteria with decreased symptoms and sequelae of bacterial conjunctivitis.Active against CDC coryneform group G, Corynebacterium pseudodiphtheriticum, Corynebacterium striatum, Haemophilus influenzae, Moraxella lacunata, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus hominis, Staphylococcus lugdunensis, Streptococcus mitis group, Streptococcus oralis, Streptococcus pneumoniae and Streptococcus salivarius.

Pharmacokinetics

Absorption: Minimal absorption follows ophthalmic use.Distribution: Unknown.Metabolism and Excretion: Unknown.Half-life: 7 hr.

Time/action profile

ROUTEONSETPEAKDURATION
Ophthunknownunknown6–12 hr

Contraindications/Precautions

Contraindicated in: Contact lens use.Use Cautiously in: Obstetric: Use during pregnancy only if potential benefit justifies potential risk to fetus; Lactation: Use cautiously during lactation; Pediatric: Safe use in children <1 yr not established.

Adverse Reactions/Side Effects

Central nervous system

  • headache

Ear, Eye, Nose, Throat

  • conjunctival redness (most frequent)
  • blurred vision
  • eye irritation
  • eye pain,
  • eye pruritus.

Interactions

Drug-Drug interaction

None noted.

Route/Dosage

Ophthalmic (Adults and Children ≥1 yr) One drop in affected eye(s) three times daily (4–12 h apart) for 7 days.

Availability

Ophthalmic suspension: 0.6% 5 mL in 7.5 mL bottle

Nursing implications

Nursing assessment

  • Assess eye for signs of infection (swelling, redness, pain, discharge) prior to and periodically during therapy.

Potential Nursing Diagnoses

Risk for infection (Indications)

Implementation

  • Ophthalmic: Invert closed bottle and shake once before use. Remove cap with bottle still inverted. Tilt head back and, with bottle inverted, gently squeeze bottle to instill 1 drop in affected eye 3 times daily (4–12 hrs apart) for 7 days.

Patient/Family Teaching

  • Instruct patient to use besifloxacin as directed, even if feeling better. Do not skip doses or stop therapy early; may lead to decreased effectiveness and resistant infections. Avoid touching applicator to eye, finger, or other areas; may contaminate. Wash hands prior to instillation.
  • Caution patient to avoid wearing contact lenses during therapy.
  • Advise patient to discontinue immediately and notify health care professional if signs or rash or allergic reaction (hives, difficulty breathing, swelling of throat) occur.

Evaluation/Desired Outcomes

  • Resolution of signs and symptoms of infection.