clonal selection


clonal selection

1. The process by which T lymphocytes with receptors that react to autoantigens are destroyed in the thymus.2. The increase of particular B or T lymphocyte clones after recognition of a specific antigen to which the body has been exposed. See: negative selection; cloneSee also: selection

clonal selection

The production by an antigen of an expanding CLONE of lymphocytes from a single cell bearing a receptor complementary to the antigen.