cryopyrin

NLRP3

A gene located on chromosome 1q44 that encodes a pyrin-like protein that interacts with the apoptosis-associated speck-like protein PYCARD/ASC. NLRP3 has a caspase recruitment domain, and belongs to the NALP3 inflammasome complex; it plays a role in regulating inflammation and apoptosis.

Molecular pathology
NLRP3 mutations are associated with chronic infantile neurological cutaneous and articular (CINCA) syndrome, familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome and neonatal-onset multisystem inflammatory disease (NOMID).

cryopyrin

A protein coded for by the cold-induced auto-inflammatory syndrome 1 gene. Cryopyrin gene mutations cause three rare hereditary periodic-fever disorders. But the protein has more recently (2006) been found to be importantly involved in the production of INFLAMMATION in innate immunity. See also INFLAMMASOME.

单词	cryopyrin
释义	cryopyrin NLRP3 A gene located on chromosome 1q44 that encodes a pyrin-like protein that interacts with the apoptosis-associated speck-like protein PYCARD/ASC. NLRP3 has a caspase recruitment domain, and belongs to the NALP3 inflammasome complex; it plays a role in regulating inflammation and apoptosis. Molecular pathology NLRP3 mutations are associated with chronic infantile neurological cutaneous and articular (CINCA) syndrome, familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome and neonatal-onset multisystem inflammatory disease (NOMID). cryopyrin A protein coded for by the cold-induced auto-inflammatory syndrome 1 gene. Cryopyrin gene mutations cause three rare hereditary periodic-fever disorders. But the protein has more recently (2006) been found to be importantly involved in the production of INFLAMMATION in innate immunity. See also INFLAMMASOME.
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