dofetilide


dofetilide

 [do-fet´ĭ-līd] an antiarrhythmic that prolongs the duration of the cardiac action potential and the effective refractory period without affecting conduction velocity; used in the treatment of atrial arrhythmias, administered orally.

dofetilide

Tikosyn® Cardiology A selective potassium channel blocking antiarrhythmic used in CHF and left ventricular dysfunction to convert A Fib, prevent its recurrence, and ↓ risk of future hospitalization; it has no effect on mortality Contraindications Succinylcholine-type anesthesia, sick sinus syndrome, seizures Adverse events Torsade de pointes. See Atrial fibrillation.