ceftibuten

[sef-ti´bu-ten] a third-generation cephalosporin antibiotic used in treatment of bronchitis, pharyngitis, tonsillitis, and acute otitis media; administered orally.

ceftibuten

Cedax

Pharmacologic class: Third-generation cephalosporin

Therapeutic class: Anti-infective

Pregnancy risk category B

Action

Interferes with bacterial cell-wall synthesis and division by binding to cell wall, causing cell to die. Active against gram-negative and gram-positive bacteria, with expanded activity against gram-negative bacteria. Exhibits minimal immunosuppressant activity.

Availability

Capsules: 400 mg

Oral suspension: 90 mg/5 ml

Indications and dosages

➣ Acute bacterial exacerbations of chronic bronchitis caused by Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae; pharyngitis and tonsillitis caused by Streptococcus pyogenes; acute bacterial otitis media caused by H. influenzae, M. catarrhalis, and S. pyogenes
Adults and children ages 12 and older: 400 mg P.O. q 24 hours for 10 days
Children ages 12 and younger: 9 mg/kg P.O. daily for 10 days. Maximum dosage shouldn't exceed 400 mg daily.

Dosage adjustment

• Renal impairment

Off-label uses

• Urinary tract infections

Contraindications

• Hypersensitivity to cephalosporins and penicillins

Precautions

Use cautiously in:

• renal impairment, hepatic disease, biliary obstruction, phenylketonuria

• history of GI disease

• elderly patients

• pregnant or breastfeeding patients

• children.

Administration

• Obtain specimens for culture and sensitivity testing as necessary before starting therapy.

• Give oral suspension at least 1 hour before or 2 hours after a meal.

Adverse reactions

CNS: headache, lethargy, paresthesia, syncope, seizures

CV: hypotension, palpitations, chest pain, vasodilation

EENT: hearing loss

GI: nausea, vomiting, diarrhea, abdominal cramps, oral candidiasis, pseudomembranous colitis

GU: vaginal candidiasis, nephrotoxicity

Hematologic: lymphocytosis, eosinophilia, bleeding tendency, hemolytic anemia, hypoprothrombinemia, neutropenia, thrombocytopenia, agranulocytosis, bone marrow depression

Hepatic: hepatic failure, hepatomegaly

Musculoskeletal: arthralgia

Respiratory: dyspnea

Skin: urticaria, easy bruising, maculopapular or erythematous rash

Other: chills, fever, superinfection, anaphylaxis, serum sickness

Interactions

Drug-drug. Aminoglycosides, loop diuretics: increased risk of nephrotoxicity

Probenecid: decreased excretion and increased blood level of ceftibuten

Drug-diagnostic tests. Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, bilirubin, blood urea nitrogen, creatinine, eosinophils, gamma-glutamyltransferase, lactate dehydrogenase: increased levels
Coombs' test, urinary 17-ketosteroids, nonenzyme-based urine glucose tests (such as Clinitest): false-positive results

Hemoglobin, platelets, white blood cells: decreased values

Drug-herbs. Angelica, anise, arnica, asafetida, bogbean, boldo, celery, chamomile, clove, danshen, fenugreek, feverfew, garlic, ginger, ginkgo, ginseng, horse chestnut, horseradish, licorice, meadowsweet, onion, papain, passionflower, poplar, prickly ash, quassia, red clover, turmeric, wild carrot, wild lettuce, willow: increased risk of bleeding

Patient monitoring

• Assess CBC and kidney and liver function test results.

• Monitor for signs and symptoms of superinfection and other serious adverse reactions.

• Be aware that cross-sensitivity to penicillins may occur.

Patient teaching

• Instruct patient to take oral suspension at least 1 hour before or 2 hours after a meal.

• Inform diabetic patient that oral suspension contains 1 g sucrose per teaspoon.

• Advise patient to continue to take full amount prescribed even when he feels better.

• Tell patient to report signs and symptoms of allergic response and other adverse reactions, such as rash, easy bruising, bleeding, severe GI problems, or difficulty breathing.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, and herbs mentioned above.

ceftibuten

(sĕf-tī′byo͞o-tn)n. A broad-spectrum cephalosporin antibiotic, C₁₅H₁₄N₄O₆S₂, used primarily to treat ear and respiratory infections.

ceftibuten

Cedax^® A once-daily broad-spectrum cephalosporin used for acute bacterial otitis media, acute bacterial exacerbation of chronic bronchitis, pharyngitis/tonsillitis. See Cephalosporin.

单词	ceftibuten
释义	ceftibuten cef·ti·bu·ten C5190290 (sĕf-tī′byo͞o-tn)n. A broad-spectrum cephalosporin antibiotic, C₁₅H₁₄N₄O₆S₂, used primarily to treat ear and respiratory infections. [cef(a)- + t(h)i(azole) + buten(e).] ceftibuten ceftibuten [sef-ti´bu-ten] a third-generation cephalosporin antibiotic used in treatment of bronchitis, pharyngitis, tonsillitis, and acute otitis media; administered orally. ceftibuten Cedax *Pharmacologic class: Third-generation cephalosporin Therapeutic class: Anti-infective Pregnancy risk category B* Action Interferes with bacterial cell-wall synthesis and division by binding to cell wall, causing cell to die. Active against gram-negative and gram-positive bacteria, with expanded activity against gram-negative bacteria. Exhibits minimal immunosuppressant activity. Availability Capsules: 400 mg Oral suspension: 90 mg/5 ml Indications and dosages ➣ Acute bacterial exacerbations of chronic bronchitis caused by Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae; pharyngitis and tonsillitis caused by Streptococcus pyogenes; acute bacterial otitis media caused by H. influenzae, M. catarrhalis, and S. pyogenes Adults and children ages 12 and older: 400 mg P.O. q 24 hours for 10 days Children ages 12 and younger: 9 mg/kg P.O. daily for 10 days. Maximum dosage shouldn't exceed 400 mg daily. Dosage adjustment • Renal impairment Off-label uses • Urinary tract infections Contraindications • Hypersensitivity to cephalosporins and penicillins Precautions Use cautiously in: • renal impairment, hepatic disease, biliary obstruction, phenylketonuria • history of GI disease • elderly patients • pregnant or breastfeeding patients • children. Administration • Obtain specimens for culture and sensitivity testing as necessary before starting therapy. • Give oral suspension at least 1 hour before or 2 hours after a meal. Adverse reactions CNS: headache, lethargy, paresthesia, syncope, seizures CV: hypotension, palpitations, chest pain, vasodilation EENT: hearing loss GI: nausea, vomiting, diarrhea, abdominal cramps, oral candidiasis, pseudomembranous colitis GU: vaginal candidiasis, nephrotoxicity Hematologic: lymphocytosis, eosinophilia, bleeding tendency, hemolytic anemia, hypoprothrombinemia, neutropenia, thrombocytopenia, agranulocytosis, bone marrow depression Hepatic: hepatic failure, hepatomegaly Musculoskeletal: arthralgia Respiratory: dyspnea Skin: urticaria, easy bruising, maculopapular or erythematous rash Other: chills, fever, superinfection, anaphylaxis, serum sickness Interactions Drug-drug. Aminoglycosides, loop diuretics: increased risk of nephrotoxicity Probenecid: decreased excretion and increased blood level of ceftibuten Drug-diagnostic tests. Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, bilirubin, blood urea nitrogen, creatinine, eosinophils, gamma-glutamyltransferase, lactate dehydrogenase: increased levels Coombs' test, urinary 17-ketosteroids, nonenzyme-based urine glucose tests (such as Clinitest): false-positive results Hemoglobin, platelets, white blood cells: decreased values Drug-herbs. Angelica, anise, arnica, asafetida, bogbean, boldo, celery, chamomile, clove, danshen, fenugreek, feverfew, garlic, ginger, ginkgo, ginseng, horse chestnut, horseradish, licorice, meadowsweet, onion, papain, passionflower, poplar, prickly ash, quassia, red clover, turmeric, wild carrot, wild lettuce, willow: increased risk of bleeding Patient monitoring • Assess CBC and kidney and liver function test results. • Monitor for signs and symptoms of superinfection and other serious adverse reactions. • Be aware that cross-sensitivity to penicillins may occur. Patient teaching • Instruct patient to take oral suspension at least 1 hour before or 2 hours after a meal. • Inform diabetic patient that oral suspension contains 1 g sucrose per teaspoon. • Advise patient to continue to take full amount prescribed even when he feels better. • Tell patient to report signs and symptoms of allergic response and other adverse reactions, such as rash, easy bruising, bleeding, severe GI problems, or difficulty breathing. • As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, and herbs mentioned above. ceftibuten (sĕf-tī′byo͞o-tn)n. A broad-spectrum cephalosporin antibiotic, C₁₅H₁₄N₄O₆S₂, used primarily to treat ear and respiratory infections. ceftibuten Cedax^® A once-daily broad-spectrum cephalosporin used for acute bacterial otitis media, acute bacterial exacerbation of chronic bronchitis, pharyngitis/tonsillitis. See Cephalosporin.
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ceftibuten

cef·ti·bu·ten

ceftibuten

ceftibuten

ceftibuten

Action

Availability

Indications and dosages

Dosage adjustment

Off-label uses

Contraindications

Precautions

Administration

Adverse reactions

Interactions

Patient monitoring

Patient teaching

ceftibuten

ceftibuten