conformational exposure

A technique of identification of abnormal proteins in which conformational epitopes that become exposed when a protein is misfolded are identified. The most impressive recent use of this technique was revealed in late 2003 when a method of detecting the protease-resistant prion protein PrP^Sc was published. Researchers found three amino acid residues, Arg-Arg-Tyr, that occurred twice in this protein. Rabbits were immunized with peptides based on this motif and were used to generate a polyclonal antibody that was able to identify PrP^Sc, in vitro, from cows, sheep and humans.

单词	conformational exposure
释义	conformational exposure conformational exposure A technique of identification of abnormal proteins in which conformational epitopes that become exposed when a protein is misfolded are identified. The most impressive recent use of this technique was revealed in late 2003 when a method of detecting the protease-resistant prion protein PrP^Sc was published. Researchers found three amino acid residues, Arg-Arg-Tyr, that occurred twice in this protein. Rabbits were immunized with peptides based on this motif and were used to generate a polyclonal antibody that was able to identify PrP^Sc, in vitro, from cows, sheep and humans.
随便看	mannose-6-phosphate mannose 6-phosphateiinsulin-like growth factor 2 receptor mannose 6-phosphate receptor, cation-independent mannose-6-phosphate receptors mannose-6-phosphate reductase mannose binding c-type lectin dc-signr mannose binding lectin mannose-binding lectin mannose-binding lectins mannose binding protein mannose-binding protein mannose c-type lectin receptor mannose-inhibitable adhesin-t7 receptor mannose-p-dolichol utilization defect mannose phosphate isomerase mannosephosphate isomerase mannose phosphate receptor mannose receptor, c-type 1 mannose receptor, c-type-1-like 1 mannose receptor, c-type 2 mannose receptor-like 1 mannose receptor-like 2 mannose receptor-like 3 mannose receptor-like protein 1 mannose receptor-like protein 2