extended-spectrum beta-lactamase


extended-spectrum beta-lactamase

Third generation cephalosporinase Microbiology A beta-lactamase produced by gram-negative enteric bacteria, in particular K pneumoniae and E coli, which are resistant to third-generation cephalosporins. See Third-generation cephalosporin.

extended-spectrum beta-lactamase

Abbreviation: ESBL
Any enzyme that makes bacteria (esp. gram-negative bacteria such as the Enterobacteriaceae) resistant to the effects of broad-spectrum beta-lactam antibiotics.See also: beta-lactamase