erythropoietin

e·ryth·ro·poi·e·tin

E0206100 (ĭ-rĭth′rō-poi-ē′tĭn)n.1. A glycoprotein hormone that stimulates the production of red blood cells by stem cells in bone marrow. Produced mainly by the kidneys, it is released in response to decreased levels of oxygen in body tissue.2. Epoetin alfa.

[erythropoiet(ic) + -in.]

erythropoietin

(ɪˌrɪθrəʊpɔɪˈiːtɪn) n (Biochemistry) a hormone, secreted by the kidney in response to low levels of oxygen in the tissues, that increases the rate of erythropoiesis. It has been used as a performance-enhancing drug for athletes and racehorses. Abbreviation: EPO

e•ryth•ro•poi•e•tin

(ɪˌrɪθ roʊˈpɔɪ ɪ tn, -pɔɪˈit n)

n. a hormone that stimulates production of red blood cells and hemoglobin in the bone marrow. [1945–50]

Thesaurus

Noun

erythropoietin - a glycoprotein secreted by the kidneys that stimulates the production of red blood cellsglycoprotein - a conjugated protein having a carbohydrate component

Translations

Erythropoietin

erythropoietin

[ə‚rith·rə′pȯi·ət·ən] (biochemistry) A hormone, thought to be produced by the kidneys, that regulates erythropoiesis, at least in higher vertebrates.

Erythropoietin

a hormone that stimulates the formation of erythrocytes in bone marrow. Characterized as a glycoprotein, erythropoietin has a carbohydrate content of 35 percent. It has a molecular weight of 30,000–40,000 and possesses antigenic properties. Erythropoietin is inactivated by neuraminidase, trypsin, chymotrypsin, and papain.

Erythropoietin was discovered by the French researchers F. Corneau and C. de Flandre in 1906 in rabbit serum that they tested after drawing blood. The hormone is found in low concentrations under normal physiological conditions, but the levels increase when the subject is in a state of hypoxia as a result of the loss of blood, a decrease in the oxygen content of the air, or various forms of anemia. Most scientists believe that erythropoietin is formed in the kidneys. When the hormone acts on stem cells in bone marrow, it causes their differentiation into cells of the erythroid series.

REFERENCES

Fedorov, N. A., and M. G. Kakhetelidze. Eritropoetin. Moscow, 1973.
Normal’noe krovetvorenie i ego reguliatsiia. Moscow, 1976.
Gordon, A. S. Regulation of Hematopoiesis, vol. 1. New York [1970].

N. A. FEDOROV

erythropoietin

enUK

erythropoietin

[ĕ-rith″ro-poi´ĕ-tin] a glycoprotein hormone secreted by the kidney in the adult and by the liver in the fetus, which acts on stem cells of the bone marrow to stimulate red blood cell production (erythropoiesis).recombinant human erythropoietin epoetin.

e·ryth·ro·poi·e·tin (EPO),

(ĕ-rith'rō-poy'ĕ-tin), [MIM*133170] A protein containing sialic acid that enhances erythropoiesis by stimulating formation of proerythroblasts and release of reticulocytes from bone marrow; it is formed by the kidney and liver, and possibly by other tissues, and can be detected in human plasma and urine. Synonym(s): erythropoietic hormone (2) , hematopoietin, hemopoietin

erythropoietin

(ĭ-rĭth′rō-poi-ē′tĭn)n.1. A glycoprotein hormone that stimulates the production of red blood cells by stem cells in bone marrow. Produced mainly by the kidneys, it is released in response to decreased levels of oxygen in body tissue.2. Epoetin alfa.

EPO

A gene on chromosome 7q22 that encodes erythropoietin, a secreted, glycosylated cytokine found in the plasma, which regulates red cell production by promoting erythroid differentiation and initiating haemoglobin synthesis. Erythropoietin plays a neuroprotective role in response to brain injury and is antiapoptotic.
Molecular pathology
Genetic variability of EPO has been linked to microvascular complications of diabetes type 2, including diabetic retinopathy, nephropathy leading to end-stage renal disease, and neuropathy

erythropoietin

EPO Physiology A 46 kD glycoprotein colony-stimulating factor produced predominantly by cells adjacent to the proximal renal tubules in response to signals from an oxygen-sensitive substances in the kidneys–eg, heme Adverse effects Chest pain, swelling, tachycardia, headache, HTN; erythropoietin–EP binds to receptors in erythroid precursors that mature into RBCs; EP is ↑ by hypoxia or by ectopic production from tumors–eg, cerebellar hemangioblastoma, hepatoma, pheochromocytoma, uterine leiomyoma, and renal cell carcinoma; it may not be ↑ in anemic premature infants, and is ↓ in 2º anemia, chronic inflammation, P vera, and certain CAs and may be useful in myeloma-related anemia; EP therapy is indicated for HIV-related anemia, anemia of renal failure and prematurity; it ↑ number of units of autologous RBCs that may be donated before surgery, for ↑ number of units that may be phlebotomized in Pts with hemochromatosis and to ↑ units that may be drawn from a person with a rare blood type

e·ryth·ro·poi·e·tin

(ĕ-rith'rō-poy'ĕ-tin) A protein that enhances erythropoiesis by stimulating formation of proerythroblasts and releasing reticulocytes from bone marrow; secreted mainly by the kidney and possibly by other tissues.

Erythropoietin

A hormone produced by the kidneys that stimulates the production of red blood cells by bone marrow.Mentioned in: Dialysis, Kidney

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REFERENCES

erythropoietin

erythropoietin

e·ryth·ro·poi·e·tin (EPO),

erythropoietin

EPO

erythropoietin

e·ryth·ro·poi·e·tin

Erythropoietin

erythropoietin

Words related to erythropoietin

noun a glycoprotein secreted by the kidneys that stimulates the production of red blood cells

Related Words