Crixivan
Noun | 1. | Crixivan - a protease inhibitor (trade name Crixivan) used for treating HIV |
单词 | crixivan | |||
释义 | Crixivan
Crixivanindinavir sulfatePharmacologic class: Protease inhibitor Therapeutic class: Antiretroviral Pregnancy risk category C ActionInhibits replication, function, and maturation of human immunodeficiency virus (HIV) protease, an enzyme essential to formation of infectious virus. As a result, further spread of virus is prevented. AvailabilityCapsules: 100 mg, 200 mg, 333 mg, 400 mg Indications and dosages➣ HIV infection Adults: 800 mg P.O. q 8 hours Dosage adjustment• Mild to moderate hepatic insufficiency secondary to cirrhosis Contraindications• Hypersensitivity to drug or its components • Concurrent use of amiodarone, ergot derivatives, cisapride, pimozide, or oral midazolam, triazolam, alprazolam, alfuzosin, sildenafil PrecautionsUse cautiously in: • renal or severe hepatic impairment, history of renal calculi • pregnant or breastfeeding patients • children. Administration• Know that drug is usually given with other antiretrovirals. • Give with full glass of water on empty stomach 1 hour before or 2 hours after meals. • If GI upset occurs, give with a light meal. See Don't give concurrently with alfuzosin, amiodarone, sildenafil, cisapride (not available in U.S.), ergot derivatives, midazolam, pimozide, or triazolam. ![]() Adverse reactionsCNS: depression, dizziness, headache, drowsiness, malaise, asthenia CV: angina, myocardial infarction EENT: oral paresthesia GI: nausea, vomiting, diarrhea, abdominal pain or distention, dyspepsia, acid regurgitation, pancreatitis GU: dysuria, crystalluria, nephrolithiasis or urolithiasis leading to renal insufficiency or failure, interstitial nephritis Hematologic: anemia, acute hemolytic anemia, increased spontaneous bleeding (in hemophiliacs) Hepatic: jaundice, hepatic dysfunction, hepatic failure Metabolic: new onset or exacerbation of diabetes mellitus, hyperglycemia Musculoskeletal: joint or back pain Respiratory: cough, dyspnea Skin: urticaria, rash, pruritus Other: abnormal taste, increased or decreased appetite, body fat redistribution or accumulation, fever, anaphylactoid reactions InteractionsDrug-drug. Azole antifungals, delavirdine, interleukins: elevated indinavir blood level, greater risk of toxicity Cisapride, ergot derivatives, midazolam, pimozide, triazolam: CYP3A4 inhibition by indinavir, leading to increased blood levels of these drugs and dangerous reactions Didanosine, efavirenz, rifamycins: decreased indinavir effects Drug-diagnostic tests. Alanine aminotransferase, amylase, aspartate aminotransferase, bilirubin, cholesterol, glucose, triglycerides: increased values Hemoglobin, neutrophils, platelets: decreased values Drug-food. Any food: decreased indinavir absorption Drug-herbs. St. John's wort: decreased indinavir blood level Patient monitoring• Assess fluid intake and output to ensure adequate hydration and help prevent nephrolithiasis or urolithiasis. • Monitor for adverse GI and CNS effects. • Evaluate liver function test results. Assess for hyperbilirubinemia. • Monitor cholesterol, glucose, and CBC with white cell differential. Patient teaching• Tell patient to take 1 hour before or 2 hours after meals with a full glass of water. • If GI upset occurs, advise patient to take with a light meal. See Instruct patient to report severe nausea or diarrhea, fever, chills, flank pain, urine or stool color changes, yellowing of skin or eyes, or personality changes. • Tell patient that drug doesn't cure HIV infection and that its long-term effects are largely unknown. • As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, foods, and herbs mentioned above. Crixivan(krĭk′sə-văn)Crixivan®Indinavir, see there.CrixivanA brand name for INDINAVIR.Crixivan
Synonyms for Crixivan
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