| 释义 |
DictionarySeeDNAEncyclopediaSeeligaseDNA ligase
ligase [li´gās, lig´ās] any of a class of enzymes that catalyze the joining together of two molecules coupled with the breakdown of a pyrophosphate bond in ATP or a similar triphosphate.DNA ligase either of two enzymes that join two double-helical molecules of DNA together to make a longer DNA molecule.ligase chain reaction a type of amplification" >DNA amplification that uses ligase" >DNA ligase to link chains and amplify the template containing the sequence in question.DNA li·gasean enzyme that leads to the formation of a phosphodiester bond at a break of one strand in duplex DNA; a part of the DNA repair system.DNA ligase an enzyme that catalyses the formation of covalent bonds between adjacent parts of a broken DNA POLYNUCLEOTIDE CHAIN. In this way a PHOSPHODIESTER BOND is formed between a 3'-OH group of one part of the chain and a 5'-PO4 group of the adjacent part. DNA ligase has a role in DNA replication and DNA REPAIR. It is also used in the formation of recombinant DNA molecules in GENETIC ENGINEERING. |