bridging necrosis


necrosis

 [nĕ-kro´sis, ne-kro´sis] (Gr.) the morphological changes indicative of cell death caused by enzymatic degradation.aseptic necrosis necrosis without infection or inflammation.acute tubular necrosis acute renal failure with mild to severe damage or necrosis of tubule cells, usually secondary to either nephrotoxicity, ischemia after major surgery, trauma (see crush syndrome), severe hypovolemia, sepsis, or burns. See also lower nephron nephrosis.Balser's fatty necrosis gangrenous pancreatitis with omental bursitis and disseminated patches of necrosis of fatty tissues.bridging necrosis septa of confluent necrosis bridging adjacent central veins of hepatic lobules and portal triads characteristic of subacute hepatic necrosis.caseous necrosis caseation (def. 2).central necrosis necrosis affecting the central portion of an affected bone, cell, or lobule of the liver.cheesy necrosis caseation (def. 2).coagulation necrosis death of cells, the protoplasm of the cells becoming fixed and opaque by coagulation of the protein elements, the cellular outline persisting for a long time.colliquative necrosis liquefactive necrosis.fat necrosis necrosis in which fat is broken down into fatty acids and glycerol, usually occurring in subcutaneous tissue as a result of trauma.liquefactive necrosis necrosis in which the necrotic material becomes softened and liquefied.massive hepatic necrosis massive, usually fatal, necrosis of the liver, a rare complication of viral hepatitis (fulminant hepatitis) that may also result from exposure to hepatotoxins or from drug hypersensitivity.moist necrosis necrosis in which the dead tissue is wet and soft.postpartum pituitary necrosis see postpartum pituitary necrosis.selective myocardial cell necrosis myofibrillar degeneration.subcutaneous fat necrosis of newborn a benign, self-limited disease affecting term newborns and young infants, characterized by circumscribed, indurated, nodular areas of fat necrosis. It is thought to be related to trauma on bony prominences during delivery, hypothermia, asphyxia, or maternal diabetes; it usually resolves spontaneously by 2 to 4 weeks with no scarring. Called also adiponecrosis neonatorum or subcutanea.Zenker's necrosis degeneration" >hyaline degeneration and necrosis of striated muscle; called also Zenker's degeneration.

bridging necrosis

A term of art for confluent necrosis seen by light microscopy, which links vascular structures (terminal hepatic (centrilobular) venules) to portal tracts (central-portal bridging necrosis). Necrosis and inflammation linking adjacent portal tracts without involving terminal venules should not be called bridging, because such lesions have different pathogenetic significance—e.g., widening of portal tracts, with or without periportal necrosis.
Cause
Severe acute hepatitis; distribution is irregular even within the same biopsy. Central–central bridging necrosis may occur in parenchymal hypoperfusion and venous outflow obstruction; presence of bridging necrosis is a reliable criterion for diagnosing chronic active hepatitis, a disease which may evolve to cirrhosis or precede liver cancer.