| Acronym | Definition |
|---|
| CISC➣Complex Instruction Set Computer |
| CISC➣Canadian Institute of Steel Construction |
| CISC➣Cisco Certification |
| CISC➣Circuit Switch |
| CISC➣Criminal Intelligence Service Canada |
| CISC➣Clean Intermittent Self-Catheterization (urology) |
| CISC➣Commonwealth Information Security Center (Virginia) |
| CISC➣CRTC Interconnection Steering Committee (Canadian Radio-television and Telecommunications Commission) |
| CISC➣Center for Forskning I Idræt, Sundhed og Civilsamfund (Denmark) |
| CISC➣City University of New York Institute for Sustainable Cities (New York, NY) |
| CISC➣Central Instructional Support Center |
| CISC➣Criminal Investigation Service Command |
| CISC➣Construction Industry Stabilization Committee (now defunct) |
| CISC➣Congress of the International Society of Citriculture |
| CISC➣Configuration Interaction with Size-Consistency |
| CISC➣Creative Integrated Solutions Consortium |
| CISC➣Clare Immigrant Support Centre (Ireland) |
| CISC➣Computer & Information Sciences Course (academia) |