brain-gut axis

brain-gut axis

A functional neurogastrointestinal unit which links the endocrine and nervous systems through hormonal peptides—e.g., bombesin, CCK, enkephalin, gastrin, neurotensin, somatostatin, substance P, VIP and others—that also serve as neurotransmitters.

brain-gut ax·is

(brān-gŭt ak'sis) The continuous feedback loop between sensory neurons in the gastrointestinal tract and motor response generated in the central nervous system. Hypersensitivity in the brain-gut axis contributes to functional GI disorders, including irritable bowel syndrome.