| 单词 | acromegaly | |||
| 释义 | acromegalyenUKac·ro·meg·a·lyA0065300 (ăk′rō-mĕg′ə-lē)acromegaly(ˌækrəʊˈmɛɡəlɪ)ac•ro•meg•a•ly(ˌæk rəˈmɛg ə li)n. acromegaly
acromegalyenUKacromegaly(ăk'rōmĕg`əlē), adult endocrine disorder resulting from hypersecretion of growth hormone produced by the pituitary gland. Since the bones cannot increase in length after full growth is attained, there is a disproportionate thickening of bones, predominantly in the skull and small bones of the hands and feet. Fingers and toes become broadened and spadelike, the skull increases in size, and the cheek bones and jaws protrude. Many of the soft tissues, such as the tongue and liver, enlarge. Frequently glucose metabolism is disturbed, leading to diabetes mellitus. Acromegaly is usually caused by a tumor of the pituitary; treatment consists of irradiation or surgical removal of the tumor. Onset of the disease can also occur in children, before the epiphyses of the bones are closed. In such cases the disorder leads to gigantismgigantism,condition in which an animal or plant is far greater than normal in size. Plants are often deliberately bred to increase their size. However, among animals, gigantism is usually the result of hereditary and glandular disturbance. ..... Click the link for more information. . Acromegalya disease associated with disruption of the functioning of the anterior lobe of the hypothesis (adenohypophysis); it is accompanied by enlargement (broadening and thickening) of the wrists, feet, skull (especially the facial portion), and other parts. Acromegaly usually appears following maturation; its development is gradual, extending over many years. It is the result of excessive production of somatotropin. Analogous disruption of hypophysis activity in immature individuals is called gigantism. Acromegaly is accompanied by cephalalgia, fatigability, weakening of intellectual capacity, visual disorders, and frequently sexual impotence in men and amenorrhea in women. Its treatment consists of surgery of the hypophysis or roentgenotherapy. REFERENCESBaranov, V. G. Bolezni endokrinnoi sistemy i obmena veshchestv, 2nd ed. Moscow, 1955.Rukovodstvo po klinicheskoi endokrinologii. Edited by E. A. Vasiukova. Moscow, 1958. acromegaly[‚ak·rō′meg·ə·lē]acromegalyenUKacromegaly[ak″ro-meg´ah-le] ac·ro·meg·a·ly(ak'rō-meg'ă-lē), [MIM*102200]acromegaly(ăk′rō-mĕg′ə-lē)acromegalyA disease caused by excess growth hormone (GH) by anterior pituitary or extrapituitary origin that occurs after the closure of epiphyseal plates after puberty. Excess GH production that precedes the closure of the epiphyseal growth plates results in gigantism in afflicted children and adolescentsAetiology Secretion of GH by anterior pituitary; GH-releasing hormone by hypothalamic tumours; ectopic GH production by small-cell carcinoma of lung, carcinoids, islet cell tumours, adrenal adenomas or other endocrine tumours. Clinical findings Coarsened, enlarged facies, lips, tongue, nose, jaw, hands, feet, supraorbital ridge and frontal bones, widely spaced teeth, bone proliferation in extremities, soft tissue thickening, hyperhidrosis, macroglossia, headache, amenorrhoea, impotence, somnolence, moodiness, glucose intolerance, cardiomegaly with heart failure (acromegalic heart disease), hypertension, carpal tunnel syndrome, sleep apnoea. Management Surgery—endonasal transphenoidal excision of the pituitary tumour; medical—somatostatin analogues (e.g., octreotide, lanreotide, which inhibit growth hormone production); in unresponsive cases dopamine agonists may work. acromegalyEndocrinology A disease of adults due to excess hGH secretion of anterior pituitary or extrapituitary origin, or due to excess secretion of GH-RH by hypothalamic tumors or ectopic hGH production by small cell carcinoma of the lungs, carcinoids, islet cell tumors, adrenal adenomas or other 'endocrine' tumors Clinical Coarsened, enlarged facies, lips, nose, jaw, hands, feet, and frontal bones, widely spaced teeth, bone proliferation in extremities, soft tissue thickening, hyperhidrosis, macroglossia, headache, amenorrhea, impotence, somnolence, moodiness, glucose intolerance, HTN, heart disease, carpal tunnel syndrome, sleep apnea. See Giantism. See Acromegaloidism.ac·ro·meg·a·ly(ak'rō-meg'ă-lē)acromegalyA serious disorder resulting from overproduction of growth hormone by the pituitary gland during adult life, after the growing ends of the bones (the epiphyses) have fused and the normal growth process is complete. The condition is usually the result of a benign tumour of the pituitary gland. There is no change in body height, but gradual enlargement of the jaw, tongue, nose, ribs, hands and feet occurs. There is also CUTIS VERTICIS GYRATA. If excessive growth hormone production occurs before the epiphyses have fused the result is gigantism. Acromegaly is treated by removing the cause.acromegalya chronic disease characterized by enlargement of the head, hands and feet, causing gigantism. It is caused by over-secretion of growth hormones from the anterior PITUITARY GLAND.Acromegalyac·ro·meg·a·ly(ak'rō-meg'ă-lē) [MIM*102200]acromegalyenUK
Synonyms for acromegaly
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acromegaly - enlargement of bones of hands and feet and face; often accompanied by headache and muscle pain and emotional disturbances; caused by overproduction of growth hormone by the anterior pituitary gland (due to a tumor)