cilastatin


cilastatin

 [si″lah-stat´in] an enzyme inhibitor used with imipenem to decrease the metabolism of imipenem in the kidneys and increase its concentration in the urine; administered as the sodium salt.

cilastatin

A drug used in combination with the beta-lactam antibiotic imipenem (carbapenem) to prevent its degradation in the kidneys so that its action can be prolonged. A brand name for the combination is Primaxin IV.