chronic myeloid leukaemia

An indolent leukaemia, characterised by increased mature granulocytes in the peripheral circulation.
Clinical findings
Often asymptomatic; otherwise with splenomegaly, left sided pain, general malaise, joint pain, low-grade fever, pancytopaenia resulting in increased infections, anaemia, thrombocytopaenia.

Genetics
Philadelphia chromosome, a fusion gene bcl-abl from a 9:22 translocation, resulting in a gene product with tyrosine kinase activity.
Management
Imatinib mesylate induces major cytogenetic responses in 60% of patients with chronic-phase CML and complete haematologic responses in 95% of CML patients.

chronic myeloid leukaemia

A myeloproliferative disorder caused by a constitutively active BCR-ABL tyrosinase kinase. It has been found that continuous treatment of chronic phase chronic myeloid leukaemia with the drug imatinib can induce durable responses of five years or more in a high proportion of patients

单词	chronic myeloid leukaemia
释义	chronic myeloid leukaemia chronic myeloid leukaemia An indolent leukaemia, characterised by increased mature granulocytes in the peripheral circulation. Clinical findings Often asymptomatic; otherwise with splenomegaly, left sided pain, general malaise, joint pain, low-grade fever, pancytopaenia resulting in increased infections, anaemia, thrombocytopaenia. Genetics Philadelphia chromosome, a fusion gene bcl-abl from a 9:22 translocation, resulting in a gene product with tyrosine kinase activity. Management Imatinib mesylate induces major cytogenetic responses in 60% of patients with chronic-phase CML and complete haematologic responses in 95% of CML patients. chronic myeloid leukaemia A myeloproliferative disorder caused by a constitutively active BCR-ABL tyrosinase kinase. It has been found that continuous treatment of chronic phase chronic myeloid leukaemia with the drug imatinib can induce durable responses of five years or more in a high proportion of patients
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