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alkylating agent
alkylating agent (ˈælkɪˌleɪtɪŋ) n (Pharmacology) any cytotoxic drug containing alkyl groups, such as chlorambucil, that acts by damaging DNA; widely used in chemotherapyThesaurus| Noun | 1. | alkylating agent - an antineoplastic drug used to treat some forms of cancerantineoplastic, antineoplastic drug, cancer drug - any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiting and hair loss and suppression of bone marrow functionchlorambucil, Leukeran - an alkalating agent (trade name Leukeran) used to treat some kinds of cancer |
alkylating agent
al·kyl·at·ing a·genta drug or chemical that, through the formation of covalent bonds, forms a derivatized tissue constituent permanently containing part of the drug or chemical compound; frequently carcinogenic and mutagenic, but often used in the chemotherapy of cancer (for example, nitrogen mustards and carmustine).alkylating agent Molecular biology An organic compound able to transfer an alkyl group to a nucleotide Oncology A generic term for any of a family of chemotherapeutics that cause irreversible damage to tumor cells and apoptotic destruction Route of administration IV, oral Adverse reactions Stomatitis, N&V, diarrhea, skin rash, anemia, alopecia; with cyclophosphamide, hemorrhagic cystitis, cardiac toxicity. Cf Antimetabolite, Plant alkaloid, Topoisomerase inhibitor. al·kyl·at·ing a·gent (alki-lāt-ing ājĕnt) Drug or chemical that, through the formation of covalent bonds, forms a derivatized tissue constituent permanently containing part of the drug or chemical compound. alkylating agent A drug which interferes with DNA synthesis by adding an alkyl group and preventing the uncoiling of the strands. This halts DNA replication so that cells cannot reproduce, an effect useful in the treatment of cancer. Drugs in this group include nitrogen mustard, CHLORAMBUCIL, CYCLOPHOSPHAMIDE, BUSULPHAN (busulfan) and thiotepa.Alkylating agentA chemical that alters the composition of the genetic material of rapidly dividing cells, such as cancer cells, causing selective cell death; used as a topical chemotherapeutic agent to treat CTCL.Mentioned in: Alemtuzumab, Cutaneous T-Cell LymphomaFinancialSeeagentalkylating agent
Words related to alkylating agentnoun an antineoplastic drug used to treat some forms of cancerRelated Words- antineoplastic
- antineoplastic drug
- cancer drug
- chlorambucil
- Leukeran
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