chlorzoxazone

relaxant

[re-lak´sant] 1. causing relaxation.2. an agent that causes relaxation.muscle relaxant an agent that specifically aids in reducing muscle tension.

chlorzoxazone

Parafon Forte DSC, Strifon Forte (CA)

Pharmacologic class: Autonomic nervous system agent

Therapeutic class: Skeletal muscle relaxant (centrally acting)

Pregnancy risk category C

Action

Unclear. Thought to act on spinal cord and subcortical levels of brain, inhibiting multisynaptic reflex arcs responsible for skeletal muscle activity.

Availability

Caplets: 500 mg

Tablets: 250 mg, 500 mg

Indications and dosages

➣ Adjunct to rest and physical therapy in treatment of muscle spasms associated with acute, painful musculoskeletal conditions

Adults: 250 to 750 mg P.O. three to four times daily

Contraindications

• Hypersensitivity to drug

• Hepatic impairment

Precautions

Use cautiously in:

• underlying cardiovascular disease, renal impairment

• children (safety not established).

Administration

• If desired, crush tablets and mix contents with food or water.

• Don't withdraw drug abruptly.

Adverse reactions

CNS: dizziness, drowsiness, light-headedness, malaise, headache, over-stimulation, tremor

GI: nausea, vomiting, constipation, diarrhea, heartburn, abdominal distress, anorexia

GU: orange or purplish-red urine

Hepatic: hepatic dysfunction

Skin: allergic dermatitis, urticaria, erythema, pruritus, petechiae, ecchymosis, angioedema

Other: allergic reactions

Interactions

Drug-drug. CNS depressants (including antihistamines, antidepressants, opioids, sedative-hypnotics): increased risk of CNS depression

Drug-diagnostic tests. Alanine aminotransferase, alkaline phosphatase, bilirubin: increased levels

Drug-herbs. Chamomile, hops, kava, skullcap, valerian: increased CNS depression

Drug-behaviors. Alcohol use: increased sedation

Patient monitoring

See Stay alert for signs and symptoms of hepatic dysfunction. Withhold drug and notify prescriber if these occur.

• Monitor hepatic enzyme and serum electrolyte levels.

Patient teaching

See Instruct patient to promptly report yellowing of eyes or skin.

• Caution patient not to consume alcohol during therapy.

• Instruct patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• Tell patient that drug may turn his urine orange or purplish-red.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.

单词	chlorzoxazone
释义	DictionarySeerelaxant chlorzoxazone chlorzoxazone [klȯr′zäks·ə‚zōn] (pharmacology) C₇H₄ClNO₂ Crystals with a melting point of 191-191.5°C; soluble in aqueous solutions of alkali hydroxides and in ammonia; used as a skeletal muscle relaxant. chlorzoxazone relaxant [re-lak´sant] 1. causing relaxation.2. an agent that causes relaxation.muscle relaxant an agent that specifically aids in reducing muscle tension. chlorzoxazone Parafon Forte DSC, Strifon Forte (CA) *Pharmacologic class:* Autonomic nervous system agent *Therapeutic class:* Skeletal muscle relaxant (centrally acting) *Pregnancy risk category C* Action Unclear. Thought to act on spinal cord and subcortical levels of brain, inhibiting multisynaptic reflex arcs responsible for skeletal muscle activity. Availability Caplets: 500 mg Tablets: 250 mg, 500 mg Indications and dosages ➣ Adjunct to rest and physical therapy in treatment of muscle spasms associated with acute, painful musculoskeletal conditions Adults: 250 to 750 mg P.O. three to four times daily Contraindications • Hypersensitivity to drug • Hepatic impairment Precautions Use cautiously in: • underlying cardiovascular disease, renal impairment • children (safety not established). Administration • If desired, crush tablets and mix contents with food or water. • Don't withdraw drug abruptly. Adverse reactions CNS: dizziness, drowsiness, light-headedness, malaise, headache, over-stimulation, tremor GI: nausea, vomiting, constipation, diarrhea, heartburn, abdominal distress, anorexia GU: orange or purplish-red urine Hepatic: hepatic dysfunction Skin: allergic dermatitis, urticaria, erythema, pruritus, petechiae, ecchymosis, angioedema Other: allergic reactions Interactions Drug-drug. CNS depressants (including antihistamines, antidepressants, opioids, sedative-hypnotics): increased risk of CNS depression Drug-diagnostic tests. Alanine aminotransferase, alkaline phosphatase, bilirubin: increased levels Drug-herbs. Chamomile, hops, kava, skullcap, valerian: increased CNS depression Drug-behaviors. Alcohol use: increased sedation Patient monitoring See Stay alert for signs and symptoms of hepatic dysfunction. Withhold drug and notify prescriber if these occur. • Monitor hepatic enzyme and serum electrolyte levels. Patient teaching See Instruct patient to promptly report yellowing of eyes or skin. • Caution patient not to consume alcohol during therapy. • Instruct patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness. • Tell patient that drug may turn his urine orange or purplish-red. • As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.
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