endostatin

en·do·stat·in

E0137750 (ĕn′dō-stăt′n)n. A naturally occurring antiangiogenic protein that inhibits the proliferation of endothelial cells and is under investigation for use in the treatment of diseases associated with abnormal blood vessel growth, including certain cancerous tumors.

[endo(thelial) + -stat + -in.]

endostatin

enUK

endostatin

(en'dō-stat-in), An endogenously produced antiangiogenic protein, a proteolytic fragment of collagen XVIII, that inhibits endothelial cell proliferation, angiogenesis and tumor growth, and stimulates endothelial apoptotic cell death. The proapoptoic activity appears to be mediated through tyrosine kinase signaling and a reduction of the antiapoptoic proteins Bcl-2 and Bcl-XL. [endo- + G. statos, stalled, arrested, + -in]

endostatin

(ĕn′dō-stăt′n)n. A potent, naturally occurring antiangiogenic protein that inhibits the formation of the blood vessels that feed tumors. It is under investigation as a potential cancer therapy.

endostatin

(ĕn″dŏ-stăt′ĭn) A protein fragment of collagen that contributes to the regulation of blood vessel growth. It is being investigated for its potential to shrink malignant tumors by decreasing their blood supply.

endostatin

A substance that interferes with the development of the lining of blood vessels (endothelium). Since cancers require blood vessels to grow and tumour endothelium divides up to 50 times faster than normal endothelium, this substance offers promise as an anticancer drug. Trials in mice have been remarkably promising and human trials are under way. See also ANGIOSTATIN.

单词	endostatin
释义	endostatin enUK en·do·stat·in E0137750 (ĕn′dō-stăt′n)n. A naturally occurring antiangiogenic protein that inhibits the proliferation of endothelial cells and is under investigation for use in the treatment of diseases associated with abnormal blood vessel growth, including certain cancerous tumors. [endo(thelial) + -stat + -in.] endostatin enUK endostatin (en'dō-stat-in), An endogenously produced antiangiogenic protein, a proteolytic fragment of collagen XVIII, that inhibits endothelial cell proliferation, angiogenesis and tumor growth, and stimulates endothelial apoptotic cell death. The proapoptoic activity appears to be mediated through tyrosine kinase signaling and a reduction of the antiapoptoic proteins Bcl-2 and Bcl-XL. [endo- + G. statos, stalled, arrested, + -in] endostatin (ĕn′dō-stăt′n)n. A potent, naturally occurring antiangiogenic protein that inhibits the formation of the blood vessels that feed tumors. It is under investigation as a potential cancer therapy. endostatin (ĕn″dŏ-stăt′ĭn) A protein fragment of collagen that contributes to the regulation of blood vessel growth. It is being investigated for its potential to shrink malignant tumors by decreasing their blood supply. endostatin A substance that interferes with the development of the lining of blood vessels (endothelium). Since cancers require blood vessels to grow and tumour endothelium divides up to 50 times faster than normal endothelium, this substance offers promise as an anticancer drug. Trials in mice have been remarkably promising and human trials are under way. See also ANGIOSTATIN.
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