单词 | d4 receptor |
释义 | D4 receptorD4 receptorNeurology A receptor present on GABAergic neurons in the cerebral cortex, hippocampus, thalamic reticular nucleus, globus pallidus, and substantia nigra–pars reticulata; D4R is of clinical interest given its high affinity for clozapine, an atypical neuroleptic agent, which ↓ the positive and negative symptoms in acutely psychotic and treatment-resistant schizophrenics, without producing extrapyramidal signs; a recent report suggests that this effect may be due to D4R-mediated GABA modulation through disinhibition of excitatory transmission in intrinsic cortical, thalamocortical, and extrapyramidal pathways |
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