epithelioid sarcoma

malignant mesenchymal tumor showing nodular, granulomalike growth of eosinophilic epithelioid and spindle cells palisading around the centrally located necrotic areas. Two subtypes are recognized: a classical distal and a fibromalike form. Tumors typically occur in the subcutaneous tissue along the tendons and fascia.

epithelioid sarcoma

A rare, low-grade sarcoma, which primarily affects the distal extremities, especially the hand and fingers. Male:female ratio, 2:1, affecting patients age 10–35 if distal and older if proximal.

DiffDx-benign
Benign fibrous histiocytoma, fibromatosis, granuloma annulare, infectious granuloma, myositis ossificans, necrobiosis lipoidica, necrobiotic granuloma, nodular fasciitis, rhabdoid tumour, rheumatoid nodule.

DiffDx-malignant
Adnexal carcinoma, clear-cell carcinoma, epithelioid vascular neoplasm, fibrosarcoma, melanoma, metastatic carcinoma, squamous cell carcinoma, synovial sarcoma.
Management
Wide local excision or amputation.

Prognosis
Recurrence in 35–75%; 40–45% metastasise—e.g., to lung, regional lymph nodes, scalp; 5-year survival in 80%; 10-year survival in 50%.
Adverse prognosticators
Deep, > 5 cm, high mitotic rate, vessel and nerve invasion, recurrence, nodal metastasis.
Epithelioid sarcoma types
Conventional (diffuse) form
Affects distal extremities, especially hand and fingers; male:female ratio, 2:1; affects patients age 10–35 if distal and older if proximal.
Proximal type
Older patients; more aggressive than conventional (distal) type; located deep in the pelvis, perineum, pubis, vulva and penis.
Micro
Large epithelioid cells with marked atypia and prominent nucleoli, varying amounts of rhabdoid features.

epithelioid sarcoma

A low-grade sarcoma of the upper extremity, ♂:♀ ratio, 2:1, of Pts age 10-35 Treatment Wide local excision or amputation DiffDx-Benign Fibromatosis, fibrous histiocytoma, nodular fasciitis, infectious granuloma, necrobiosis lipoidica, rheumatoid nodule DiffDx-malignant Synovial sarcoma, fibrosarcoma, melanoma Prognosis Recurrence is common; 45% metastasize–eg, to lung, regional lymph nodes, scalp

单词	epithelioid sarcoma
释义	epithelioid sarcoma epithelioid sarcoma malignant mesenchymal tumor showing nodular, granulomalike growth of eosinophilic epithelioid and spindle cells palisading around the centrally located necrotic areas. Two subtypes are recognized: a classical distal and a fibromalike form. Tumors typically occur in the subcutaneous tissue along the tendons and fascia. epithelioid sarcoma A rare, low-grade sarcoma, which primarily affects the distal extremities, especially the hand and fingers. Male:female ratio, 2:1, affecting patients age 10–35 if distal and older if proximal. DiffDx-benign Benign fibrous histiocytoma, fibromatosis, granuloma annulare, infectious granuloma, myositis ossificans, necrobiosis lipoidica, necrobiotic granuloma, nodular fasciitis, rhabdoid tumour, rheumatoid nodule. DiffDx-malignant Adnexal carcinoma, clear-cell carcinoma, epithelioid vascular neoplasm, fibrosarcoma, melanoma, metastatic carcinoma, squamous cell carcinoma, synovial sarcoma. Management Wide local excision or amputation. Prognosis Recurrence in 35–75%; 40–45% metastasise—e.g., to lung, regional lymph nodes, scalp; 5-year survival in 80%; 10-year survival in 50%. Adverse prognosticators Deep, > 5 cm, high mitotic rate, vessel and nerve invasion, recurrence, nodal metastasis. Epithelioid sarcoma types Conventional (diffuse) form Affects distal extremities, especially hand and fingers; male:female ratio, 2:1; affects patients age 10–35 if distal and older if proximal. Proximal type Older patients; more aggressive than conventional (distal) type; located deep in the pelvis, perineum, pubis, vulva and penis. Micro Large epithelioid cells with marked atypia and prominent nucleoli, varying amounts of rhabdoid features. epithelioid sarcoma A low-grade sarcoma of the upper extremity, ♂:♀ ratio, 2:1, of Pts age 10-35 Treatment Wide local excision or amputation DiffDx-Benign Fibromatosis, fibrous histiocytoma, nodular fasciitis, infectious granuloma, necrobiosis lipoidica, rheumatoid nodule DiffDx-malignant Synovial sarcoma, fibrosarcoma, melanoma Prognosis Recurrence is common; 45% metastasize–eg, to lung, regional lymph nodes, scalp
随便看	turbidimeters turbidimetric turbidimetrically turbidimetric analysis turbidimetric titration turbidimetry turbidimetryor turbidometry turbidite turbidite outcrop analog database archive and learning turbidites turbiditic turbidity turbidity, atmospheric turbidity coefficient turbidity current turbidity currents turbidity factor turbidity reducing unit turbidity removal evaporator turbidity unit turbidly turbid media turbidness turbidostat turbillion