CYP 3A

CYP 3A

a cytochrome P450 isoform found in the gastrointestinal tract as well as hepatic and other cells; substrates include benzodiazepines, calcium channel blockers, antihistamines, steroid hormones, and protease inhibitors. Inhibited by antidepressants, azole antifungals, cimetidine, grapefruit juice, and erythromycin. Induced by phenobarbital, phenytoin, rifampin, and carbamazepine.

CYP 3A

Abbreviation for a cytochrome P450 isoform found in the gastrointestinal tract as well as hepatic and other cells; substrates include benzodiazepines, calcium channel blockers, antihistamines, steroid hormones, and protease inhibitors. Inhibited by antidepressants, azole antifungals, cimetidine, and erythromycin. Induced by phenobarbital, phenytoin, rifampin, and carbamazepine.