| 单词 |
epidermal growth factor receptor |
| 释义 |
epidermal growth factor receptor
epidermal growth factor receptor (EGFR), [MIM*131550] receptor often upregulated in epithelial tumors.EGFR A gene on chromosome 7p12 that encodes epidermal growth factor, a transmembrane glycoprotein of the protein kinase superfamily, which is a receptor for members of the epidermal growth factor family. Binding of the protein to a ligand induces receptor dimerisation and tyrosine autophosphorylation and leads to cell proliferation.
Molecular pathology
EGFR mutations are associated with lung cancer.ep·i·der·mal growth fac·tor re·cep·tor (EGFR) (ep'i-dĕr'măl grōth fak'tŏr rĕ-sep'tŏr) Receptor often upregulated in epithelial tumors. See EFGR
See EGF-R |
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