colon polyp

Gastroenterology A hereditary or acquired pedunculated neoplasm arising from the colonic mucosa; small CPs are usually benign, but may become malignant; like colorectal CA, CPs may present with occult bleeding. See Polyp, Colorectal cancer. Colon polyp Acquired polyps Adenomatous or tubular–villous in morphology, ↑ frequency with age; although often asymptomatic, larger polyps are often announced by bleeding or changed bowel habits; if very large, APs may form a leading 'front' of an intussusception; distinction between adenomatous polyps–'tight' round glands and villous adenomas–finger-like fronds of elongated glands has little practical importance–both have malignant potential; periodic colonoscopy and polypectomy yields a 3-fold ↑ in subsequent cancer; hyperplastic polyps are also acquired but are non-neoplastic Hereditary polyps • Familial adenomatous polyposis A premalignant, AD condition presenting in early adulthood with 100s to 1000s of colonic polyps, related to a loss of the normal repression of DNA synthesis in the entire colonic epithelium; adenocarcinoma occurs in 70–100% of Pts, prevented by prophylactic colectomy • Gardner syndrome A rare AD condition with premalignant polyps of the entire GI tract, which is identical to FAP, but has, in addition, extraintestinal tumors; most Pts develop colon carcinoma; other neoplasms in GS Pts include bile duct carcinoma, osteomas of mandible, skull, and long bones, soft tissue tumors–fibromas, lipomas, sebaceous cysts, and rarely, thyroid and adrenal gland cancers

单词	colon polyp
释义	colon polyp colon polyp Gastroenterology A hereditary or acquired pedunculated neoplasm arising from the colonic mucosa; small CPs are usually benign, but may become malignant; like colorectal CA, CPs may present with occult bleeding. See Polyp, Colorectal cancer. Colon polyp Acquired polyps Adenomatous or tubular–villous in morphology, ↑ frequency with age; although often asymptomatic, larger polyps are often announced by bleeding or changed bowel habits; if very large, APs may form a leading 'front' of an intussusception; distinction between adenomatous polyps–'tight' round glands and villous adenomas–finger-like fronds of elongated glands has little practical importance–both have malignant potential; periodic colonoscopy and polypectomy yields a 3-fold ↑ in subsequent cancer; hyperplastic polyps are also acquired but are non-neoplastic Hereditary polyps • Familial adenomatous polyposis A premalignant, AD condition presenting in early adulthood with 100s to 1000s of colonic polyps, related to a loss of the normal repression of DNA synthesis in the entire colonic epithelium; adenocarcinoma occurs in 70–100% of Pts, prevented by prophylactic colectomy • Gardner syndrome A rare AD condition with premalignant polyps of the entire GI tract, which is identical to FAP, but has, in addition, extraintestinal tumors; most Pts develop colon carcinoma; other neoplasms in GS Pts include bile duct carcinoma, osteomas of mandible, skull, and long bones, soft tissue tumors–fibromas, lipomas, sebaceous cysts, and rarely, thyroid and adrenal gland cancers
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