Zollinger-Ellison syndrome

[zol´in-jer el´ĭ-sun] a triad comprising intractable, sometimes fulminating, atypical peptic ulcers; extreme gastric hyperacidity; and non--beta-cell, gastrin-secreting islet cell tumors (gastrinomas) of the pancreas, which may be single or multiple, small or large, benign or malignant.

Zol·lin·ger-El·li·son syn·drome (ZES),

(zŏl'inj-er el'ĭ-son), [MIM*131100] peptic ulceration with gastric hypersecretion and gastrinoma of the pancreas or duodenum, sometimes associated with familial multiple endocrine adenomatosis type 1.

Zol·lin·ger-El·li·son syn·drome (ZES),

Zollinger-Ellison syndrome

(zŏl′ĭn-jər-ĕl′ĭ-sən)n. A gastrointestinal disease characterized by chronic peptic ulcers, gastric hypersecretion, and pancreatic gastrinomas.

Zollinger-Ellison syndrome

A condition characterized by multiple duodenal ulcers and gastrin-secreting tumors that cause recurrent and refractory upper GI ulceration, diarrhea, steatorrhea, hypoglycemia–due to excess 'little' gastrin, pyrosis and dysphagia due to gastroesophageal reflux and ↑ gastric acid; 25% also have MEN-I; malignant gastric carcinoid may be related to chronic gastrin hypersecretion Diagnosis CT, typical clinical findings Lab ↑ Gastrin, ↑ basal acid output–>15 mmol/hr, ↑ post-histamine stimulation acid production, ↑ ratio of basal acid output to maximum acid output–stimulation testing reveals fasting gastrin > 1000 pg/mL, ↑ Ca2+ DiffDx-hypergastrinemia Antral hyperplasia, retained antrum syndrome, chronic atrophic gastritis, pernicious anemia, short bowel syndrome, gastric outlet syndrome or obstruction, gastric CA, pheochromocytoma, renal failure Management H₂ receptor antagonists; at higher doses may be coadministered with antimuscarinics to inhibit gastric secretion by H₂ blockage; if unresponsive, total gastrectomy and/or vagotomy

Zol·lin·ger-El·li·son syn·drome

(zol'in-jĕr-el'i-sŏn sin'drōm) Peptic ulceration with gastric hypersecretion and non-beta cell tumor of the pancreatic islets, sometimes associated with familial polyendocrine adenomatosis.

Zollinger-Ellison syndrome

A severe form of stomach and duodenal ulceration caused by an excessive production of acid by the stomach. This is stimulated by one or more tumours of the pancreas, known as gastrinomas, that secrete a powerful hormone acting on the stomach. Gastrinomas are often malignant, although slow-growing. Complete surgical removal is not always possible and drugs in the H-2 receptor antagonist group, such as cimetidine, or the more recent proton pump blocking drugs, such as OMEPRAZOLE, are often used. Removal of the stomach (gastrectomy) may be necessary. (Robert Milton Zollinger, b. 1903, American surgeon; and Edwin Horner Ellison, 1918–70, American professor of Surgery).

Zollinger-Ellison syndrome

A rare condition characterized by severe and recurrent peptic ulcers in the stomach, duodenum, and upper small intestine, caused by a tumor, or tumors, usually found in the pancreas. The tumor secretes the hormone gastrin, which stimulates the stomach and duodenum to produce large quantities of acid, leading to ulceration. Most often cancerous, the tumor must be removed surgically; otherwise total surgical removal of the stomach is necessary.Mentioned in: Gastric Acid Determination, Ulcer Surgery, Ulcers (Digestive)

Ellison,

Edwin Homer, U.S. physician, 1918-1970. Zollinger-Ellison syndrome - see under ZollingerZollinger-Ellison tumor - see under Zollinger

Reichmann,

Mikola, Polish physician, 1851-1918. Reichmann disease - Synonym(s): Zollinger-Ellison syndrome

Zollinger,

Robert M., U.S. surgeon, 1903-1992. Zollinger leg holderZollinger multipurpose tissue forcepsZollinger splintZollinger-Ellison syndrome - peptic ulceration with gastric hypersecretion and non--beta cell tumor of the pancreatic islets, sometimes associated with familial polyendocrine adenomatosis.Synonym(s): Reichmann diseaseZollinger-Ellison tumor - a non-beta cell tumor of pancreatic islets causing the Zollinger-Ellison syndrome.

Zol·lin·ger-El·li·son syn·drome

(zol'in-jĕr-el'i-sŏn sin'drōm) [MIM*131100] Peptic ulceration with gastric hypersecretion and non-beta cell tumor of the pancreatic islets, sometimes associated with familial polyendocrine adenomatosis.

Zollinger-Ellison syndrome

Zollinger-Ellison syndrome

Zollinger-Ellison syndrome

Zollinger-Ellison syndrome

Zollinger-Ellison syndrome

Zol·lin·ger-El·li·son syn·drome (ZES),

Zol·lin·ger-El·li·son syn·drome (ZES),

Zollinger-Ellison syndrome

Zollinger-Ellison syndrome

Zol·lin·ger-El·li·son syn·drome

Zollinger-Ellison syndrome

Zollinger-Ellison syndrome

Ellison,

Reichmann,

Zollinger,

Zol·lin·ger-El·li·son syn·drome

Zollinger-Ellison syndrome

Words related to Zollinger-Ellison syndrome

noun syndrome consisting of intractable peptic ulceration with gastric hypersecretion and hyperacidity

Related Words