单词 | zaleplon |
释义 | zaleplonzaleplonzaleplon[zal´ĕ-plon]zaleplonPharmacologic class: Pyrazolopyrimidine, nonbenzodiazepine hypnotic Therapeutic class: Sedative-hypnotic Controlled substance schedule IV Pregnancy risk category C ActionBinds to omega-1 receptor of gamma-aminobutyric acid receptor complex, relaxing smooth muscles, reducing anxiety, and producing sedation. Also has anticonvulsant effect. AvailabilityCapsules: 5 mg, 10 mg Indications and dosages➣ Insomnia Adults younger than age 65: 10 mg P.O. at bedtime. Dosage above 20 mg is not recommended. Dosage adjustment• Mild to moderate hepatic impairment • Elderly or debilitated patients Contraindications• Hypersensitivity to drug or its components PrecautionsUse cautiously in: • tartrazine sensitivity • severe renal impairment (use not recommended), mild to moderate hepatic impairment, respiratory impairment, depression • history of suicide attempt • patients weighing less than 50 kg (110 lb) • patients older than age 65 • pregnant or breastfeeding patients (use not recommended) • children younger than age 18 (safety not established). Administration• Give at bedtime. • Don't administer with high-fat meal. ![]() Adverse reactionsCNS: headache, amnesia, anxiety, hallucinations, light-headedness, dizziness, drowsiness, depersonalization, transient memory or psychomotor impairment, incoordination, malaise, vertigo, asthenia, hyperesthesia, paresthesia, tremor CV: peripheral edema EENT: abnormal vision, eye pain, ear pain, hearing sensitivity, epistaxis GI: nausea, abdominal pain, colitis, dyspepsia, anorexia GU: dysmenorrhea Musculoskeletal: myalgia Skin: photosensitivity Other: altered sense of smell, fever InteractionsDrug-drug. Cimetidine: decreased metabolism and increased effects of zaleplon CNS depressants (including antihistamines, opioids, other sedative-hypnotics, phenothiazines, tricyclic antidepressants): additive CNS depression CYP450-3A4 inducers (such as carbamazepine, phenobarbital, phenytoin, rifampin): decreased blood level and reduced efficacy of zaleplon CYP450-3A4 inhibitors (such as erythromycin, ketoconazole): increased zaleplon blood level Drug-food. High-fat meal: delayed drug absorption Drug-herbs. Chamomile, hops, kava, skullcap, valerian: increased CNS depression Drug-behaviors. Alcohol use: increased CNS depression Patient monitoring• Monitor drug efficacy. Insomnia persisting after 7 to 10 days warrants reevaluation for underlying psychological or physical illness. • Stay alert for adverse drug reactions. Patient teaching• Explain therapy to patient. Emphasize importance of taking drug just before bedtime or after trying to sleep-but only if he will be able to get at least 4 hours of sleep. • Inform patient that high-fat meal slows drug absorption and delays drug effects. • Caution patient to avoid driving and other hazardous activities while under drug's influence. • Instruct patient to avoid alcohol during therapy. • Tell patient rebound insomnia may occur for 1 or 2 nights after he stops taking drug. • Advise female of childbearing age to notify prescriber if she is or plans to become pregnant or if she is breastfeeding. • As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, foods, herbs, and behaviors mentioned above. zaleplon(zăl′ə-plŏn′)zaleplonSonata®, see there. |
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