zafirlukast

enUK

zafirlukast

[zah-fir´loo-kast] a leukotriene receptor antagonist used in treatment of asthma, administered orally.

zafirlukast

Accolate

Pharmacologic class: Leukotriene receptor antagonist

Therapeutic class: Antiasthmatic, bronchodilator

Pregnancy risk category B

Action

Antagonizes activity of three leukotrienes at specific receptor sites in airway smooth muscle, inhibiting inflammation

Availability

Tablets (coated): 10 mg, 20 mg

Indications and dosages

➣ Prophylaxis and long-term treatment of asthma

Adults and children ages 12 and older: 20 mg P.O. b.i.d.

Children ages 5 to 11: 10 mg P.O. b.i.d.

Off-label uses

• Exercise-induced bronchospasm

• Chronic urticaria

Contraindications

• Hypersensitivity to drug or its components

• Hepatic impairment, including hepatic cirrhosis

Precautions

Use cautiously in:

• acute asthma attacks

• concurrent use of warfarin

• patients older than age 55

• pregnant patients

• breastfeeding patients (use not recommended)

• children younger than age 5 (safety not established).

Administration

• Give at least 1 hour before or 2 hours after a meal.

Adverse reactions

CNS: headache, dizziness, asthenia, insomnia, depression (especially in children and adolescents)

GI: nausea, vomiting, diarrhea, abdominal pain, dyspepsia

Hepatic: hepatic dysfunction including liver failure and death (rare)

Musculoskeletal: joint or back pain, myalgia

Other: fever, infection, pain

Interactions

Drug-drug. Aspirin: increased zafirlukast blood level

Erythromycin, theophylline: decreased zafirlukast blood level

Warfarin: increased warfarin effects, greater risk of bleeding

Drug-food. Any food: decreased rate and extent of zafirlukast absorption

Patient monitoring

• Assess patient's respiratory status to help evaluate drug efficacy.

See Monitor liver function tests closely; watch for signs and symptoms of liver dysfunction.

Patient teaching

• Tell patient to take at least 1 hour before or 2 hours after a meal.

• Advise patient to take exactly as prescribed, even if he is symptom-free.

See Tell patient to immediately report asthma attack. Advise him not to use drug for rapid relief of bronchospasm.

• Instruct patient to continue taking other asthma drugs unless prescriber directs otherwise.

See Instruct patient to immediately report signs and symptoms of liver dysfunction (nausea, anorexia, fatigue, lethargy, pruritus, jaundice, flulike symptoms, or right upper quadrant abdominal pain).

• Instruct patient or caregiver to report insomnia or depression.

• Instruct female patient to consult prescriber if she plans to breastfeed.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs and foods mentioned above.

za·fir·lu·kast

(za'fir-lū'kast), A blocker of leukotriene D₄ and E₄ (LTD₄ and LTE₄) components of a slow-reacting substance of anaphylaxis (SRSA); used for the prophylaxis of asthma attacks.

zafirlukast

(zə-fîr′lo͞o-kăst′)n. A drug, C₃₁H₃₃N₃O₆S, that acts as a leukotriene receptor antagonist, reduces the inflammatory process, and is used in the treatment of asthma.

za·fir·lu·kast

(za'fir-lū'kast) A blocker of leukotriene D₄ and E₄ (LTD₄ and LTE₄) components of a slow-reacting substance of anaphylaxis (SRSA); used for prophylaxis of asthma.

Zafirlukast (Accolate)

An inhibitor that prevents leukotrienes from binding to cell receptors; taken over time, zafirlukast can help reduce or prevent asthma symptoms.Mentioned in: Leukotriene Inhibitors

单词	zafirlukast
释义	zafirlukast enUK za·fir·lu·kast Z0000850 (zə-fîr′lo͞o-kăst′)n. A drug, C₃₁H₃₃N₃O₆S, that acts as a leukotriene receptor antagonist, reduces the inflammatory process, and is used in the treatment of asthma. [zafir- (perhaps ultimately alteration of sulfonyl) + -lukast, leukotriene receptor antagonist suff. (from rearrangement of (anti)as(thmatic) l(e)uk(otriene receptor antagonis)t).] Translations zafirlukast enUK zafirlukast [zah-fir´loo-kast] a leukotriene receptor antagonist used in treatment of asthma, administered orally. zafirlukast Accolate *Pharmacologic class:* Leukotriene receptor antagonist *Therapeutic class:* Antiasthmatic, bronchodilator *Pregnancy risk category B* Action Antagonizes activity of three leukotrienes at specific receptor sites in airway smooth muscle, inhibiting inflammation Availability Tablets (coated): 10 mg, 20 mg Indications and dosages ➣ Prophylaxis and long-term treatment of asthma Adults and children ages 12 and older: 20 mg P.O. b.i.d. Children ages 5 to 11: 10 mg P.O. b.i.d. Off-label uses • Exercise-induced bronchospasm • Chronic urticaria Contraindications • Hypersensitivity to drug or its components • Hepatic impairment, including hepatic cirrhosis Precautions Use cautiously in: • acute asthma attacks • concurrent use of warfarin • patients older than age 55 • pregnant patients • breastfeeding patients (use not recommended) • children younger than age 5 (safety not established). Administration • Give at least 1 hour before or 2 hours after a meal. Adverse reactions CNS: headache, dizziness, asthenia, insomnia, depression (especially in children and adolescents) GI: nausea, vomiting, diarrhea, abdominal pain, dyspepsia Hepatic: hepatic dysfunction including liver failure and death (rare) Musculoskeletal: joint or back pain, myalgia Other: fever, infection, pain Interactions Drug-drug. Aspirin: increased zafirlukast blood level Erythromycin, theophylline: decreased zafirlukast blood level Warfarin: increased warfarin effects, greater risk of bleeding Drug-food. Any food: decreased rate and extent of zafirlukast absorption Patient monitoring • Assess patient's respiratory status to help evaluate drug efficacy. See Monitor liver function tests closely; watch for signs and symptoms of liver dysfunction. Patient teaching • Tell patient to take at least 1 hour before or 2 hours after a meal. • Advise patient to take exactly as prescribed, even if he is symptom-free. See Tell patient to immediately report asthma attack. Advise him not to use drug for rapid relief of bronchospasm. • Instruct patient to continue taking other asthma drugs unless prescriber directs otherwise. See Instruct patient to immediately report signs and symptoms of liver dysfunction (nausea, anorexia, fatigue, lethargy, pruritus, jaundice, flulike symptoms, or right upper quadrant abdominal pain). • Instruct patient or caregiver to report insomnia or depression. • Instruct female patient to consult prescriber if she plans to breastfeed. • As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs and foods mentioned above. za·fir·lu·kast (za'fir-lū'kast), A blocker of leukotriene D₄ and E₄ (LTD₄ and LTE₄) components of a slow-reacting substance of anaphylaxis (SRSA); used for the prophylaxis of asthma attacks. zafirlukast (zə-fîr′lo͞o-kăst′)n. A drug, C₃₁H₃₃N₃O₆S, that acts as a leukotriene receptor antagonist, reduces the inflammatory process, and is used in the treatment of asthma. za·fir·lu·kast (za'fir-lū'kast) A blocker of leukotriene D₄ and E₄ (LTD₄ and LTE₄) components of a slow-reacting substance of anaphylaxis (SRSA); used for prophylaxis of asthma. Zafirlukast (Accolate) An inhibitor that prevents leukotrienes from binding to cell receptors; taken over time, zafirlukast can help reduce or prevent asthma symptoms.Mentioned in: Leukotriene Inhibitors
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