atypical measles

a·typ·i·cal mea·sles

sometimes severe, unusual clinical manifestation of natural measles virus infection in people with waning vaccination immunity, particularly in those who had received formaldehyde-inactivated vaccine; an accelerated allergic reaction apparently resulting from an anamnestic antibody response, characterized by high fever, absence of Koplik spots, a shortened prodromal period, atypical rash, and pneumonia.

atypical measles

A serious illness that occurred in children immunised with an inactivated vaccine against measles virus in the 1960s, which failed to elicit long-lived protective antibody and a cytotoxic T-lymphocyte response.
Clinical findings
High fever, headache, cough, abdominal pain, followed by rash 1 to 2 days later, often beginning on the limbs, acral oedema; pneumonia is common and may persist for 3 months or more.
Pathogenesis
Post-vaccination exposure to wild-type virus during community outbreaks was associated with immune complex deposition in affected tissues, brisk CD4+ T lymphocyte proliferative responses, and a Th2 bias of the immune response.

a·typ·i·cal mea·sles

(ā-tip'i-kăl mē'zĕlz) Unusual clinical manifestation of natural measles infection in people with waning vaccination immunity, particularly in those who had received formaldehyde-inactivated vaccine; an accelerated allergic reaction characterized by high fever, absence of Koplik spots, a shortened prodromal period, atypical rash, and pneumonia.

单词	atypical measles
释义	DictionarySeemeasles atypical measles a·typ·i·cal mea·sles sometimes severe, unusual clinical manifestation of natural measles virus infection in people with waning vaccination immunity, particularly in those who had received formaldehyde-inactivated vaccine; an accelerated allergic reaction apparently resulting from an anamnestic antibody response, characterized by high fever, absence of Koplik spots, a shortened prodromal period, atypical rash, and pneumonia. atypical measles A serious illness that occurred in children immunised with an inactivated vaccine against measles virus in the 1960s, which failed to elicit long-lived protective antibody and a cytotoxic T-lymphocyte response. Clinical findings High fever, headache, cough, abdominal pain, followed by rash 1 to 2 days later, often beginning on the limbs, acral oedema; pneumonia is common and may persist for 3 months or more. Pathogenesis Post-vaccination exposure to wild-type virus during community outbreaks was associated with immune complex deposition in affected tissues, brisk CD4+ T lymphocyte proliferative responses, and a Th2 bias of the immune response. a·typ·i·cal mea·sles (ā-tip'i-kăl mē'zĕlz) Unusual clinical manifestation of natural measles infection in people with waning vaccination immunity, particularly in those who had received formaldehyde-inactivated vaccine; an accelerated allergic reaction characterized by high fever, absence of Koplik spots, a shortened prodromal period, atypical rash, and pneumonia.
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