Working Formulation

A classification of non-Hodgkin lymphomas which was created in 1982 to improve communication among various lymphoma experts, which had been difficult due to the plethora of classifications extant up to that point. The Working Formulation was easily applied by pathologists and relatively predictive of the lymphoma’s future behaviour, based on its stratification of lymphomas into low, intermediate, and high grades. While it has been retired by bench pathologists, it may still be used by agencies that compile lymphoma statistics.
Despite the Working Formulation’s acceptance and ease of application by pathologists, it had enough fatal flaws that it was replaced by the Revised European American classification in the 1990s, which tried to apply immunophenotypic and genetic features in identifying distinct clinicopathologic entities among all the lymphomas.
Working Formulation
Low Grade
• Malignant Lymphoma—small lymphocytic (chronic lymphocytic leukaemi(1)).
• Malignant Lymphoma—follicular, predominantly small cleaved cell.
• Malignant Lymphoma—follicular, mixed (small cleaved and large cell).
Intermediate grade
• Malignant Lymphoma—follicular, predominantly large cell.
• Malignant Lymphoma—diffuse, small cleaved cell.
• Malignant Lymphoma—diffuse, mixed small and large cell.
• Malignant Lymphoma—diffuse, large cell.
High grade
• Malignant Lymphoma—large cell, immunoblastic.
• Malignant Lymphoma—lymphoblastic.
• Malignant Lymphoma—small non-cleaved cells (Burkitt's lymphom(1)).
Miscellaneous
• Composite
• Mycosis fungoides
• Histiocytic
• Extramedullary plasmacytoma
• Unclassifiable

单词	working formulation
释义	Working Formulation Working Formulation A classification of non-Hodgkin lymphomas which was created in 1982 to improve communication among various lymphoma experts, which had been difficult due to the plethora of classifications extant up to that point. The Working Formulation was easily applied by pathologists and relatively predictive of the lymphoma’s future behaviour, based on its stratification of lymphomas into low, intermediate, and high grades. While it has been retired by bench pathologists, it may still be used by agencies that compile lymphoma statistics. Despite the Working Formulation’s acceptance and ease of application by pathologists, it had enough fatal flaws that it was replaced by the Revised European American classification in the 1990s, which tried to apply immunophenotypic and genetic features in identifying distinct clinicopathologic entities among all the lymphomas. Working Formulation Low Grade • Malignant Lymphoma—small lymphocytic (chronic lymphocytic leukaemi(1)). • Malignant Lymphoma—follicular, predominantly small cleaved cell. • Malignant Lymphoma—follicular, mixed (small cleaved and large cell). Intermediate grade • Malignant Lymphoma—follicular, predominantly large cell. • Malignant Lymphoma—diffuse, small cleaved cell. • Malignant Lymphoma—diffuse, mixed small and large cell. • Malignant Lymphoma—diffuse, large cell. High grade • Malignant Lymphoma—large cell, immunoblastic. • Malignant Lymphoma—lymphoblastic. • Malignant Lymphoma—small non-cleaved cells (Burkitt's lymphom(1)). Miscellaneous • Composite • Mycosis fungoides • Histiocytic • Extramedullary plasmacytoma • Unclassifiable
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