wheal-and-flare reaction


wheal-and-er·y·the·ma re·ac·tion

the characteristic immediate reaction observed in an allergy skin test; within 10-15 minutes after injection of antigen (allergen), an irregular, blanched, elevated wheal appears, surrounded by an area of erythema (flare). Synonym(s): wheal-and-flare reaction

wheal-and-flare reaction

Triple response of Lewis Immunology A series of 3 sequential responses that occur in skin subjected to minor trauma, caused by tissue release of histamine; WFR tests immediate hypersensitivity–'reaginic' or allergic reaction to an antigen, and can be transferred to a nonallergic person. See P-K test.

wheal-and-er·y·the·ma re·ac·tion

(wēl er'i-thē'mă rē-ak'shŭn) The characteristic immediate reaction observed in the skin test; within 10-15 minutes after injection of antigen (allergen), an irregular, blanched, elevated wheal appears, surrounded by an area of erythema (flare).
Synonym(s): wheal-and-flare reaction.