telmisartan

[tel″mĭ-sahr´tan] an angiotensin II antagonist used as an antihypertensive, administered orally.

telmisartan

Micardis

Pharmacologic class: Angiotensin II receptor antagonist

Therapeutic class: Antihypertensive

Pregnancy risk category C (first trimester), D (second and third trimesters)

FDA Box Warning

Drugs that act directly on the renin-angiotensin system can cause injury to or death of a developing fetus. Discontinue drug as soon as possible when pregnancy is detected.

Action

Inhibits vasoconstricting effects and blocks aldosterone-producing effects of angiotensin II at various receptor sites, including vascular smooth muscle and adrenal glands

Availability

Tablets: 20 mg, 40 mg, 80 mg

Indications and dosages

➣ Hypertension

Adults: 40 mg P.O. daily, titrated up or down within range of 20 to 80 mg daily based on response and tolerance

➣ Cardiovascular risk reduction

Adults: 80 mg P.O. daily in patients unable to take angiotensin-converting enzyme (ACE) inhibitors

Contraindications

• Hypersensitivity to drug or its components

Precautions

Use cautiously in:

• heart failure, impaired renal function secondary to primary renal disease or renal stenosis, obstructive biliary disorders, hepatic impairment, volume or sodium depletion

• patients receiving high-dose diuretics

• concomitant use of ACE inhibitors and angiotensin receptor blockers (avoid use)

• pregnant or breastfeeding patients

• children younger than age 18 (safety not established).

Administration

• Don't remove tablet from blister pack until just before giving.

• Know that drug may be used alone or with other antihypertensives.

Adverse reactions

CNS: dizziness, headache, fatigue

CV: chest pain, peripheral edema, hypertension, intermittent claudication

EENT: sinusitis, pharyngitis

GI: nausea, vomiting, diarrhea, dyspepsia, abdominal pain

GU: urinary tract infection

Musculoskeletal: myalgia, back and leg pain

Respiratory: cough, upper respiratory infection

Skin: ulcer

Other: pain, flu or flulike symptoms, hypersensitivity

Interactions

Drug-drug. Antihypertensives, diuretics: increased risk of hypotension

Ace inhibitors (ramipril): increased ramipril steady-state C_max and area under the curve (AUC), decreased telmisartan C_max and AUC

Digoxin: increased digoxin blood level

Lithium: increased serum lithium concentration and toxicity

Nonsteroidal anti-inflammatory drugs, including selective cyclooxygenase-2 inhibitors): deterioration of renal function, including possible acute renal failure in elderly patients, volume-depleted patients (including those on diuretic therapy), or with compromised renal function; attenuated telmisartan antihypertensive effect

Drug-diagnostic tests. Creatinine: slight elevation

Drug-food. Any food: slightly reduced drug bioavailability

Patient monitoring

• Monitor blood pressure frequently and watch for signs and symptoms of hypotension.

• Closely monitor patient with impaired hepatic or renal function. Correct volume deficits as appropriate before therapy starts. Monitor fluid intake and output and creatinine level during therapy.

Patient teaching

• Tell patient to take 1 hour before or 2 hours after meals.

• Caution patient not to remove tablet from blister pack until just before taking.

• Advise patient to report swelling or chest pain.

• Teach patient to measure blood pressure regularly and report significant changes.

• Tell patient to report suspected pregnancy to prescriber. Caution her not to breastfeed.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, tests, and foods mentioned above.

telmisartan

(tĕl′mĭ-sär′tăn)n. An angiotensin II receptor blocker drug, C₃₃H₃₀N₄O₂, used primarily to treat hypertension.

telmisartan

Micardis^® Cardiology An angiotensin II receptor antagonist for treating HTN. See Angiotensin II receptor antagonist.

单词	telmisartan
释义	telmisartan tel·mi·sar·tan T5103950 (tĕl′mĭ-sär′tăn)n. An angiotensin II receptor blocker drug, C₃₃H₃₀N₄O₂, used primarily to treat hypertension. [telmi-, of unknown origin + -sartan, angiotensin II receptor blocker suffix; see losartan.] Translations telmisartan telmisartan [tel″mĭ-sahr´tan] an angiotensin II antagonist used as an antihypertensive, administered orally. telmisartan Micardis *Pharmacologic class:* Angiotensin II receptor antagonist *Therapeutic class:* Antihypertensive *Pregnancy risk category C* (first trimester), D (second and third trimesters) FDA Box Warning Drugs that act directly on the renin-angiotensin system can cause injury to or death of a developing fetus. Discontinue drug as soon as possible when pregnancy is detected. Action Inhibits vasoconstricting effects and blocks aldosterone-producing effects of angiotensin II at various receptor sites, including vascular smooth muscle and adrenal glands Availability Tablets: 20 mg, 40 mg, 80 mg Indications and dosages ➣ Hypertension Adults: 40 mg P.O. daily, titrated up or down within range of 20 to 80 mg daily based on response and tolerance ➣ Cardiovascular risk reduction Adults: 80 mg P.O. daily in patients unable to take angiotensin-converting enzyme (ACE) inhibitors Contraindications • Hypersensitivity to drug or its components Precautions Use cautiously in: • heart failure, impaired renal function secondary to primary renal disease or renal stenosis, obstructive biliary disorders, hepatic impairment, volume or sodium depletion • patients receiving high-dose diuretics • concomitant use of ACE inhibitors and angiotensin receptor blockers (avoid use) • pregnant or breastfeeding patients • children younger than age 18 (safety not established). Administration • Don't remove tablet from blister pack until just before giving. • Know that drug may be used alone or with other antihypertensives. Adverse reactions CNS: dizziness, headache, fatigue CV: chest pain, peripheral edema, hypertension, intermittent claudication EENT: sinusitis, pharyngitis GI: nausea, vomiting, diarrhea, dyspepsia, abdominal pain GU: urinary tract infection Musculoskeletal: myalgia, back and leg pain Respiratory: cough, upper respiratory infection Skin: ulcer Other: pain, flu or flulike symptoms, hypersensitivity Interactions Drug-drug. Antihypertensives, diuretics: increased risk of hypotension Ace inhibitors (ramipril): increased ramipril steady-state C_max and area under the curve (AUC), decreased telmisartan C_max and AUC Digoxin: increased digoxin blood level Lithium: increased serum lithium concentration and toxicity Nonsteroidal anti-inflammatory drugs, including selective cyclooxygenase-2 inhibitors): deterioration of renal function, including possible acute renal failure in elderly patients, volume-depleted patients (including those on diuretic therapy), or with compromised renal function; attenuated telmisartan antihypertensive effect Drug-diagnostic tests. Creatinine: slight elevation Drug-food. Any food: slightly reduced drug bioavailability Patient monitoring • Monitor blood pressure frequently and watch for signs and symptoms of hypotension. • Closely monitor patient with impaired hepatic or renal function. Correct volume deficits as appropriate before therapy starts. Monitor fluid intake and output and creatinine level during therapy. Patient teaching • Tell patient to take 1 hour before or 2 hours after meals. • Caution patient not to remove tablet from blister pack until just before taking. • Advise patient to report swelling or chest pain. • Teach patient to measure blood pressure regularly and report significant changes. • Tell patient to report suspected pregnancy to prescriber. Caution her not to breastfeed. • As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, tests, and foods mentioned above. telmisartan (tĕl′mĭ-sär′tăn)n. An angiotensin II receptor blocker drug, C₃₃H₃₀N₄O₂, used primarily to treat hypertension. telmisartan Micardis^® Cardiology An angiotensin II receptor antagonist for treating HTN. See Angiotensin II receptor antagonist. ThesaurusSeeRestoril
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telmisartan

tel·mi·sar·tan

telmisartan

telmisartan

telmisartan

FDA Box Warning

Action

Availability

Indications and dosages

Contraindications

Precautions

Administration

Adverse reactions

Interactions

Patient monitoring

Patient teaching

telmisartan

telmisartan