traumatic axonal injury

A post-traumatic form of diffuse brain injury which affects the white matter, and is divided into three grades by histology.
Traumatic axonal injury
Grade 1: Abnormalities are identified by histology only.
Grade 2: Widely distributed axonal damage, plus focal lesion in the corpus callosum.
Grade 3: Diffuse axonal damage, plus focal lesions in the corpus callosum and the brainstem.
Diagnosis
Immunocytochemistry for amyloid precursor protein A-beta-PP, which can be identified in all patients who survive 3+ hours after traumatic head injury. A-beta-PP can also be seen in infarction, hypoglycaemia, and HIV infection. Long-standing lesions can be identified by CD68, a marker of microglial activation.

单词	traumatic axonal injury
释义	traumatic axonal injury traumatic axonal injury A post-traumatic form of diffuse brain injury which affects the white matter, and is divided into three grades by histology. Traumatic axonal injury Grade 1: Abnormalities are identified by histology only. Grade 2: Widely distributed axonal damage, plus focal lesion in the corpus callosum. Grade 3: Diffuse axonal damage, plus focal lesions in the corpus callosum and the brainstem. Diagnosis Immunocytochemistry for amyloid precursor protein A-beta-PP, which can be identified in all patients who survive 3+ hours after traumatic head injury. A-beta-PP can also be seen in infarction, hypoglycaemia, and HIV infection. Long-standing lesions can be identified by CD68, a marker of microglial activation.
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